Fetal behavior
Neurobiology of AgingPublished 1 May 2003
Jan G. Nijhuis
Citations83
SJR quartileQ1
SJR score1.45
SNIP0.92
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TL;DR
No single test can predict with certainty if the fetus is compromised and/or what the optimal timing is for the delivery.
Abstract
Fetal behavior reflects the activity of the fetal central nervous system (CNS). Insight in fetal behavior is crucial for the understanding of normal fetal well-being and in the evaluation of the possibly compromised fetus. In order to recognize 'behavioral' patterns, linkage of variables (absence of movements, absence of eye movements, heart rate patterns) is obligatory. No single test can predict with certainty if the fetus is compromised and/or what the optimal timing is for the delivery. That is why the study of fetal behavior is very time-consuming. Development of more appropriate methods to analyze fetal behavior should have high priority in clinical perinatology.
Keywords
Medicine
Early Human DevelopmentThe emergence of fetal behaviour. I. Qualitative aspects
901 Citations1982Johanna I.P. de Vries, Gerard H. A. Visser +1 more
The emergence of spontaneous fetal motility during the first 20 weeks of gestation was studied longitudinally in 11 healthy nulliparae, using real-time ultrasound to study the onset and developmental course of spontaneously generated specific fetal movement patterns.
Early Human DevelopmentAre there behavioural states in the human fetus?
815 Citations1982Jan G. Nijhuis, H.F.R. Prechtl +2 more
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Early Human DevelopmentMotor behaviour in the growth retarded fetus
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Early Human DevelopmentEmergence of behavioural states in fetuses of type-1-diabetic women
379 Citations1987E Mulder, Gerhard H. Visser +2 more
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Early Human DevelopmentThe emergence of fetal behaviour. II. Quantitative aspects
325 Citations1985Johanna I.P. de Vries, Gerard H. A. Visser +1 more
The majority of movements seemed to occur at no regular interval or the regularity was missed because the burst length was too short: hiccups occurred with a preference interval of one to three seconds and isolated arm movements with an interval of about 1 s.
Journal of Perinatal MedicineSystem 8000: Computerized antenatal FHR analysis
176 Citations1991G. S. Dawes, M. Moulden +1 more
It has been interesting to observe how rarely the basal FHR changes in fetuses suffering progressive respiratory insufficiency, and how extreme tachycardia tends to reflect other fetal problems such as infection or maternal pyrexia.
PubMedPatterns of human fetal breathing during the last 10 weeks of pregnancy.
171 Citations1980John Patrick, M. Karen Campbell +3 more
The data show that much more information must be obtained on factors that normally influence fetal breathing activity before research strategies be suggested for clinical evaluation of the usefulness of fetal breathing movements in the assessment of fetal health.
BJOG An International Journal of Obstetrics & GynaecologyAntenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone
147 Citations1997E Mulder, Jan Derks +1 more
To compare the effects of maternal betamethasone and dexamethAsone administration on fetal behaviour and fetal heart rate variation, a large number of women andfetal behaviour and heart rate variations are studied.
American Journal of Obstetrics and GynecologyInterobserver and intraobserver variation in the assessment of antepartum cardiotocograms
135 Citations1982F.K. Lotgering, Henk C.S. Wallenburg +1 more
A low level of agreement between observers was shown to exist for all three systems tested, and the level of intraobserver agreement was shows to be much higher for virtually all three Systems.
BJOG An International Journal of Obstetrics & GynaecologyOBSERVER VARIABILITY IN ASSESSMENT OF ANTEPARTUM CARDIOTOCOGRAMS
133 Citations1978J.B. Trimbos, Marc J. N. C. Keirse
It is concluded that the interpretation of the antepartum CTG is not as easy nor as reproducible as one may wish, and the scoring system, which is easy to use, offers major advantages when compared to subjective assessment.
BJOG An International Journal of Obstetrics & GynaecologyNUMERICAL ANALYSIS OF THE NORMAL HUMAN ANTENATAL FETAL HEART RATE
133 Citations1981Gerhard H. Visser, G. S. Dawes +1 more
It is concluded that on scrutiny of fetal heart rate records for evidence of normality, or otherwise, due account should be taken of gestational age.
ScienceThe Development of Human Fetal Eye Movement Patterns
131 Citations1981Jason C. Birnholz
The eye can be visualized ultrasonically in more than 90 percent of fetuses 16 through 42 weeks of gestational age and is associated with sustained diaphragmatic excursions implying a "quiet sleep" state.
Early Human DevelopmentDiurnal and other variations in fetal movement and heart rate patterns at 20–22 weeks
126 Citations1987Johanna I.P. de Vries, Gerhard H. Visser +2 more
It was investigated when diurnal and other variations in fetal movements and in heart rate pattern emerge during the course of pregnancy to confirm earlier findings that the rank order of movements is strictly age dependent.
American Journal of Obstetrics and GynecologyIn utero cocaine exposure: Observations of fetal behavioral state may predict neonatal outcome
100 Citations1989Roderick F. Hume, Karen O’Donnell +3 more
Findings support the concepts that cocaine exposure disrupts central nervous system development and that fetal assessment of state is predictive of neonatal outcome and Disorganized behavioral state in the fetus successfully predicted abnormal newborn behavior.
Early Human DevelopmentBehavioural states in growth-retarded human fetuses
94 Citations1985M.A.T. van Vliet, Chester B. Martin +2 more
The growth-retarded fetuses showed differences in the quality and quantity of somatic motility in comparison to low risk fetuses of equivalent gestational age, and these observations suggest that some aspects of central nervous system function are disturbed in growth- retarding fetuses, even in the absence of fetal distress.
NeuropediatricsOrganization of Physiological Parameters in Normal and Neurologically Abnormal Infants
85 Citations1969H.F.R. Prechtl, H Weinmann +1 more
A series of mathematical models are suggested to help in the analysis of the statistical properties of the separate parameters as well as of their interrelationships of infants recorded with the aid of polygraphic techniques.
Early Human DevelopmentHuman fetal eye movements: Detection in utero by ultrasonography
77 Citations1981R.S.G.M. Bots, Jan G. Nijhuis +2 more
A comparison of direct echoscopic detection of eye movements in a 3-day-old neonate confirmed that the movements observed in the orbital region with the real-time scanner corresponded well with eye movements seen directly.
The LancetFetal learning and memory
71 Citations2000Cathelijne F. van Heteren, Peter F. Boekkooi +2 more
It is concluded that fetuses are able to learn: they have a short-term memory of at least 10 min, and a long-termMemory of at at least 24 h.
American Journal of Obstetrics and GynecologyNumeric analysis of heart rate variation in intrauterine growth-retarded fetuses: A longitudinal study
70 Citations1992R. J. M. Snijders, L. S. M. Ribbert +2 more
In fetuses with intrauterine growth retardation a decrease in long-term fetal heart rate variation is a rather late sign of impairment that coincides with the occurrence of late decelerations.
BMJEffect of cigarette smoking on fetal breathing movements in normal pregnancies.
70 Citations1975F.A. Manning, E.W. Pugh +1 more
In 18 women with uncomplicated pregnancies smoking two cigarettes significantly reduced the proportion of the time that fetal breathing movements were present.
Pediatric ResearchFetal Behavior at 30 to 32 Weeks of Gestation
63 Citations1987G.H.A. Visser, G Poelman-Weeshes +2 more
It is concluded that at this gestational age heart rate variation and eye and gross body movements are not independent variables and that coordination among the cyclic patterns of these variables starts well before 36 wk.
Early Human DevelopmentBehavioural state transitions in healthy and growth retarded fetuses
63 Citations1989Domenico Arduini, Giuseppe Rizzo +4 more
The analysis of transitions differentiates between healthy fetuses and those affected by IUGR, and a significant trend in the change of state variables was evident inhealthy fetuses.
American Journal of Obstetrics and GynecologyThe relationship between fetal activity and behavioral states and fetal breathing movements in normal and growth-retarded fetuses
63 Citations1985M.A.T. van Vliet, Chester B. Martin +2 more
The mean incidence of fetal breathing in the low-risk fetuses was greater during active states than during the quiet state, and there was no apparent increase in the degree of linkage between fetal breathing and other expressions of fetal activity after the emergence of behavioral states.
PubMedHabituation in normal and Down's syndrome fetuses.
61 Citations1992Peter G. Hepper, S. Shahidullah
It is concluded that habituation may be a powerful tool to examine the behavioural and sensory development of the fetus and may be of use in the antenatal assessment of the existence and severity of neural abnormality.
Early Human DevelopmentTransient reduction in fetal activity and heart rate variation after maternal betamethasone administration
60 Citations1994E Mulder, Jan Derks +3 more
It is concluded that maternal betamethasone administration results in a considerable reduction in fetal movements and FHR variation which may erroneously be interpreted as deterioration of the fetal condition.
Early Human DevelopmentFetal behaviour in normal and compromised fetuses. An overview
56 Citations1995Carlo Romaninï, Giuseppe Rizzo
The technique of recording and analyzing fetal behaviour, its development in normal pregnancy and its influence on different physiological parameters that are assessed in clinical practice are described.
Early Human DevelopmentBehavioural states in the fetuses of nulliparous women
52 Citations1985M.A.T. van Vliet, Chester B. Martin +2 more
It is concluded that the development of behavioural states is generally similar in the Fetuses of low risk nulliparae and multiparae, but that states appear at a somewhat later gestational age in the fetuses of nullipARAe.
Early Human DevelopmentThe rhythmicity of fetal breathing varies with behavioural state in the human fetus
51 Citations1983Jan G. Nijhuis, Chester B. Martin +4 more
The rhythmicity of human fetal breathing movements was studied during two different behavioural states, using real-time B-scan-directed M-mode ultrasound recordings, demonstrating that the fetal breathing rhythm is more regular than during state 2F epochs.
Journal of Perinatal MedicineComputer-assisted analysis of normal second trimester fetal heart rate patterns
44 Citations1991L. S. M. Ribbert, V. Fidler +1 more
During the second trimester FHR variation differs considerably from that in the third trimester, and should be taken into account in the interpretation of second trregnancy FHR records.
American Journal of Obstetrics and GynecologyFetal breathing, gross fetal body movements, and maternal and fetal heart rates before spontaneous labor at term
43 Citations1984Lesley Carmichael, M. Karen Campbell +1 more
It is suggested that the presence of gross fetal body movements is a more consistent index of fetal health before spontaneous labor at term.
Early Human DevelopmentFetal habituation to vibroacoustic stimulation in relation to fetal states and fetal heart rate parameters
40 Citations2001Cathelijne F. van Heteren, Peter F. Boekkooi +2 more
Although the majority of healthy fetuses was able to habituate, the interfetal variability in habituation performance is such that testing of habituation seems not to be a sensitive tool for the assessment of the fetal CNS.
Early Human DevelopmentThe association between fetal body movements, eye movements and heart rate patterns in pregnancies between 25 and 30 weeks of gestation
38 Citations1990Adrian P. Drogtrop, Roel Ubels +1 more
It is emphasized that for the interpretation of fetal biophysical tests, gestational age should be taken into account.
European Journal of Obstetrics & Gynecology and Reproductive BiologyFetal heart rhythms during behavioural state 1F
38 Citations1988E.E. van Woerden, Herman P. van Geijn +4 more
The fetal heart rate pattern was studied in 39 enclosed periods with absence of fetal eye and body movements and the heart rate deviated from the definition for FHRP A, i.e. a sinusoidal-like rhythm associated with sucking movements.
Prenatal DiagnosisThe fetal behavioural states: An ultrasonic study
36 Citations1985Domenico Arduini, Giuseppe Rizzo +6 more
In order to accurately detect the fetal behavioural state, this work simultaneously measured fetal heart rate and multiple fetal activities in 27 healthy pregnant women at 38 to 40 weeks of gestation.
Early Human DevelopmentRegular and irregular human fetal respiratory movement
35 Citations1980Ilan E. Timor‐Tritsch, LeRoy J. Dierker +3 more
It would appear that the correlation of regular fetal respiratory movement with fetal quiet periods in the term fetus adds additional evidence that a quiet sleep state may exist in theterm fetus.
PubMedThe effects of methadone treatment on the reactivity of the nonstress test.
35 Citations1989Archie Cl, Lee Mi +2 more
It is suggested that methadone treatment altered the morphology of the NST, which may limit the reliability of this test for determining fetal well-being in these high-risk gravidas if time of medication is not taken into consideration.
European Journal of Obstetrics & Gynecology and Reproductive BiologyA sinusoidal-like fetal heart-rate pattern in association with fetal sucking — report of 2 cases
34 Citations1984Jan G. Nijhuis, Klaus J. Staisch +2 more
Two cases are reported in which a sinusoidal-like fetal heart-rate pattern was caused by fetal sucking movements as observed by real-time ultrasonography.
Fetal Diagnosis and TherapyDevelopment of Behavioral States in Hydrocephalic Fetuses
29 Citations1987Domenico Arduini, Giuseppe Rizzo +2 more
The degree of discordance seems to be related to the severity of neonatal outcome suggesting a possible estimation of CNS dysfunction by means of behavioral state analysis.
Early Human DevelopmentAutomated assignment of behavioural states in the human near term fetus
26 Citations1989E.E. van Woerden, Herman P. van Geijn +4 more
Thirty-five 2-h recordings of fetal heart rate and fetal movements, made at 38-39 weeks of gestational age, have been analyzed in a partly automated procedure and the advantages and disadvantages of the automated assignment of fetal behavioural states are discussed.
Early Human DevelopmentEffects of maternal glucose ingestion on human fetal breathing movements at weeks 24 and 28 of gestation
26 Citations1986Jan G. Nijhuis, Henk W. Jongsma +3 more
It is concluded that already at 24 weeks gestation the human fetus reacts with an increase of fetal breathing movements after the administration of glucose to the mother.
Early Human DevelopmentFetal behaviour in uncomplicated pregnancies after 41 weeks of gestation
24 Citations1994M. van de Pas, Jan G. Nijhuis +1 more
Journal of Perinatal MedicineLongitudinal assessment of behavioural transitions in healthy human fetuses during the third trimester of pregnancy
21 Citations1991Domenico Arduini, Giuseppe Rizzo +3 more
A progressive decrease in the duration of transitions as a function of gestational age was evidenced for both transitions from 1F to 2F and transitions from 2F to 1F.
Early Human DevelopmentFetal heart rate in early pregnancy
18 Citations1990Marijke van Heeswijk, Jan G. Nijhuis +1 more
A close correlation between crown-rump length and heart rates was established and a rapid increase of the mean heart rate was observed from 113 to 167 beats per min, followed by a slow decrease to 156 beats perMin.
European Journal of Obstetrics & Gynecology and Reproductive BiologyFetal behavioural states in epileptic pregnancies
18 Citations1986Herman P. van Geijn, J.M. Swartjes +4 more
This preliminary study, limited to mostly combined treatment with antiepileptic drugs, could not demonstrate any obvious effect on fetal neuromuscular development from maternal antiePileptic medication.
European Journal of Obstetrics & Gynecology and Reproductive BiologyBizarre fetal behaviour associated with lethal congenital anomalies: a case report
17 Citations1991Mary Pillai, Christine Garrett +1 more
Prolonged recording of behaviour was performed in a fetus at 36 weeks gestation, who was severely small for dates with no apparent aetiology, and following delivery a lethal multiple congenital abnormality syndrome was identified.
Journal of Perinatal MedicineResponses to vibroacoustic stimulation in a fetus with an encephalocele compared to responses of normal fetuses
11 Citations2000Cathelijne F. van Heteren, Peter F. Boekkooi +2 more
Observation of fetal movement and fetal heart rate responses to repeated vibroacoustic stimulation (VAS) might be useful as a measure to assess fetal well-being and to assess the integrity of the fetal central nervous system (CNS).
Early Human DevelopmentState transitions in uncomplicated pregnancies after term
10 Citations1998Jan G. Nijhuis, M. van de Pas +1 more
It is concluded that the study of transitions does not distinguish between the term and after term fetuses under optimal conditions and whether or not the analysis of state transitions can be used to distinguish 'normal' from 'abnormal' fetuses and detect the fetus at risk after term awaits further study.
Early Human DevelopmentThe intercostal-to-phrenic-inhibitory reflex (IPIR) in normal and intra-uterine growth-retarded (IUGR) human fetuses from 26 to 40 weeks of gestation
4 Citations1993Benedikt Tas, Jan G. Nijhuis +2 more
The results prove the existence of the IPIR in normal and IUGR-fetuses and the duration of theIPIR-apnea would increase during gestation and would be increased in IugR- Fetuses as compared to healthy fetuses of the same age.
Early Human DevelopmentThe intercostal-to-phrenic inhibitory reflex in the human fetus near term
4 Citations1990Benedikt Tas, Jan G. Nijhuis +2 more
In 21 healthy fetuses between 37 and 40 weeks, two real time scanners and a cardiotocograph were used to asses the fetal behavioural state and indicated that the IPIR is indeed present in both behavioural states.
Fetal and Maternal Medicine ReviewBrain function in <i>utero</i> unique to the developing fetus
1 Citations1995Takashi Koyanagi, Junichi Nabekura +1 more
Behaviour originally depends on precise and specific interconnections between nerve cells, and the nervous system develops in a series of appropriately timed steps with a temporal sequence characteristic of each neural structure.