Sudden and unexpected deaths after the administration of hexavalent vaccines (diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, Haemophilius influenzae type b): is there a signal?
European Journal of PediatricsPublished 15 December 2004
Rüdiger von Kries, André Michael Toschke, Klaus Straßburger, Michael Kundi, Helen Kalies, Uta Nennstiel
Citations58
SJR quartileQ1
SJR score0.93
SNIP1.20
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TL;DR
These findings based on spontaneous reporting do not prove a causal relationship between vaccination and sudden unexpected deaths, however, they constitute a signal for one of the two hexavalent vaccines which should prompt intensified surveillance for unexpected deaths after vaccination.
Abstract
These findings based on spontaneous reporting do not prove a causal relationship between vaccination and sudden unexpected deaths. However, they constitute a signal for one of the two hexavalent vaccines which should prompt intensified surveillance for unexpected deaths after vaccination.
Keywords
Social SciencesMedicinePharmacology, Toxicology and Pharmaceutics
American Journal of EpidemiologyConfounding in Studies of Adverse Reactions to Vaccines
173 Citations1992Paul Fine, Robert T. Chen
This paper reviews the literature on studies of severe adverse events after the administration of pertussis antigen-containing vaccines, with particular attention to the measures taken by different investigators to avoid this problem.
PEDIATRICSRisk Factors Associated with Failure to Receive Vaccinations
117 Citations1979James S. Marks, Thomas J. Halpin +3 more
By using paternal and maternal education level and family size as screening variables, children at high risk for failure to complete their immunizations could be identified prospectively and made the target of intervention programs to improve compliance.
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If measles immunization levels among preschool children in the United States are to be increased, education of both health care providers and parents, coupled with innovative strategies targeted to preschool children, particularly of low socioeconomic groups in inner cities, are needed.
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113 Citations1988Marie R. Griffin, Wayne A. Ray +2 more
It is concluded that in this large population of children there was no increase in the risk of SIDS after immunization with the DTP vaccine.
PEDIATRICSDiphtheria-Tetanus-Pertussis Immunization and Sudden Infant Death: Results of the National Institute of Child Health and Human Development Cooperative Epidemiological Study of Sudden Infant Death Syndrome Risk Factors
109 Citations1987Howard J. Hoffman, Jehu Hunter +5 more
The results confirm the earlier preliminary findings from the NICHD SIDS Cooperative Epidemiological Study and suggest that DTP immunization is not a significant factor in the occurrence of SIDS.
BMJThe UK accelerated immunisation programme and sudden unexpected death in infancy: case-control study
76 Citations2001Peter Fleming, Peter S Blair +4 more
Investigation of explained sudden infant deaths as well as the sudden infant death syndrome and took into account potential bias found immunisation uptake was lowest among the infants who died, with no temporal relation or correlation with signs and symptoms of illness.
The Pediatric Infectious Disease JournalHaemophilus influenzae type b disease: impact and effectiveness of diphtheria-tetanus toxoids-acellular pertussis (-inactivated poliovirus)/ H. influenzae type b combination vaccines
73 Citations2001Heinz‐Josef Schmitt, Rüdiger von Kries +6 more
Although it is well-documented that DTaP/Hib vaccines elicit lower anti-Hib titers than separate vaccines, such combinations are effective in reducing the incidence of invasive H. influenzae type b disease in Germany.
British Journal of Clinical PharmacologyDeterminants of signal selection in a spontaneous reporting system for adverse drug reactions
70 Citations2001Eugène van Puijenbroek, Kees van Grootheest +3 more
This study showed that selection of signals is based on both qualitative and quantitative aspects, and knowledge of these factors may improve the efficiency of the underlying signal selection process.
BMJSigns of illness preceding sudden unexpected death in infants.
68 Citations1990Ruth Gilbert, Peter Fleming +2 more
Major and minor signs of illness are neither a sensitive nor a specific indicator of sudden unexpected death of infants and have no predictive value, which may help to identify babies at risk before death.
Archives of Disease in ChildhoodA clinical comparison of SIDS and explained sudden infant deaths: how healthy and how normal?
65 Citations2000Martin Ward Platt
There are clinical features and health markers characterising increased vulnerability of infants who die suddenly and unexpectedly that are evident at birth, during life, and just before death “Baby Check” might help identify seriously ill babies at risk of sudden death, particularly in high risk infants.
Archives of Disease in ChildhoodImmunisation and the sudden infant death syndrome. New Zealand Cot Death Study Group.
65 Citations1995Edwin A. Mitchell, Angela Stewart +1 more
Immunisation does not increase the risk of SIDS and may even lower the risk, and a large nationwide case-control study used to measure immunisation status found.
British Journal of Clinical PharmacologySudden unexpected death in infants under 3 months of age and vaccination status – a case‐control study
55 Citations2001A.‐P. Jonville‐Béra, E. Autret‐Leca +2 more
DTPP+/-Hib immunization is not a risk factor for early SUD and in this population, the same risk factors as described for SIDS are found.
International Journal of EpidemiologySudden Infant Death and Immunization: An Extensive Epidemiological Approach to the Problem in France—Winter 1986
27 Citations1989M.-H. Bouvier-Colle, Antoine Flahaut +3 more
An epidemiological study was carried out in order to investigate the possibility of a relationship between diphtheria-tetanus toxoids-pertussis and inactivated poliomyelitis virus immunization of infants concerned and sudden infant death syndrome (SIDS).
Archives of Disease in ChildhoodVaccination and cot deaths in perspective.
23 Citations1987S C Roberts
In 1985 twin boys simultaneously succumbed to sudden unexpected deaths two to three hours after vaccination with diphtheria, tetanus, and pertussis vaccine (DTP), raising the question of whether an association of sudden infant death (SID) with vaccination is other than temporal.
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18 Citations1988Joanna C. Roper, Sophie Day
Comparison of uptake of the first and third triple immunisations showed a considerable initial delay for infants weighing less than 2000 g at birth compared with heavier babies, but by 18 months the coverage was almost identical and final overall uptake was poor for all groups.