Convulsants induce interleukin-1β messenger RNA in rat brain
Biochemical and Biophysical Research CommunicationsPublished 1 September 1990
Masabumi Minami, Yasushi Kuraishi, Takashi Yamaguchi, Satoru Nakai, Yoshikatsu Hirai, Masamichi Satoh
Citations157
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
These results provide the first evidence that intensive neuronal excitation induces Interleukin-1β mRNA in particular regions of the brain.
Abstract
The effects of systemic administration of kainic acid and pentylenetetrazol on interleukin-1 beta gene expression in the rat brain was studied. After the administration of kainic acid in a convulsive dose (10 mg/kg i.p.), Interleukin-1 beta mRNA was induced intensely in the cerebral cortex, thalamus and hypothalamus, moderately in the hippocampus and weakly in the striatum, but not in the midbrain, pons-medulla and cerebellum. Pentylenetetrazol induced Interleukin-1 beta mRNA in the cerebral cortex, hypothalamus, and hippocampus with a faster time-course than kainic acid. Diazepam suppressed both the convulsion and the induction of Interleukin-1 beta mRNA produced by kainic acid. Dexamethasone suppressed the induction of Interleukin-1 beta mRNA, but did neither the convulsion nor the induction of c-fos mRNA following the injection of kainic acid. These results provide the first evidence that intensive neuronal excitation induces Interleukin-1 beta mRNA in particular regions of the brain.
Keywords
Immunology and MicrobiologyNeuroscience
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