Spontaneous abortion rate and advanced maternal age: consequences for prenatal diagnosis
The LancetPublished 1 July 1990Open access
Titia E. Cohen‐Overbeek, W C Hop, M den Ouden, L. Pijpers, M. G. J. Jahoda, Juriy W. Wladimiroff
Citations46
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TL;DR
Findings justify delaying prenatal diagnosis in older pregnant women until 12 weeks of gestation because of the increased risk of abortion within 30 days of intake.
Abstract
Maternal age related and procedure-related fetal abortion rates were studied in 384 women aged 36 and over scheduled for transabdominal chorionic villus sampling (TA-CVS) at 12-14 weeks of gestation. The pre-TA-CVS abortion rate within 30 days of intake (at 6-10 weeks of gestation) rose from 1.9% at age 35-36 years to 10.9% at 40 years and older. Women entering in the 6th week of gestation had a greater probability of aborting before TA-CVS than women entering after day 48. 26 women aborted spontaneously before TA-CVS, the majority of abortions occurring at 10-12 weeks. TA-CVS was done in 346 women. 11 pregnancies were terminated because of genetic anomalies, and 8 women had spontaneous fetal loss. These findings justify delaying prenatal diagnosis in older pregnant women until 12 weeks of gestation.
Keywords
Medicine
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