Infection and labor
American Journal of Obstetrics and GynecologyPublished 1 January 1992
Roberto Romero, Moshe Mazor, Rafaella Morrotti, Cecilia Avila, E Oyarzún, A. Insunza
Citations139
SJR quartileQ1
SJR score2.77
SNIP2.75
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TL;DR
Data indicate that microbial invasion of the amniotic cavity occurs in approximately one third of patients with preterm premature rupture of membranes, which is a risk factor for endometritis in women with term premature rupturing of membranes.
Abstract
These data indicate that microbial invasion of the amniotic cavity occurs in approximately one third of patients with preterm premature rupture of membranes. Microbial invasion of the amniotic cavity is a risk factor for endometritis in women with term premature rupture of membranes.
Keywords
Medicine
American Journal of Obstetrics and GynecologyInfection and labor V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes
682 Citations1989Roberto Romero, M Sirtori +7 more
Amniotic fluid retrieved by amniocentesis from 264 patients with preterm labor and intact membranes admitted to Yale-New Haven Hospital from Jan. 1, 1985, to July 31, 1988 had a higher incidence of respiratory distress syndrome and infectious complications than preterm neonates born after negative amniotics fluid cultures.
American Journal of Obstetrics and GynecologyInfection and labor
598 Citations1992Roberto Romero, Rogelio González +7 more
Amniocentesis to determine the microbiologic characteristics of the amniotic cavity should be considered before a cerclage is placed in women presenting with cervical dilatation in the midtrimester of pregnancy.
The Journal of Infectious DiseasesQuantitative Bacteriology of Amniotic Fluid from Women with Clinical Intraamniotic Infection at Term
561 Citations1982Gibbs Rs, Jorge Blanco +2 more
Amniotic fluid was collected through an intrauterine catheter from 52 women with clinical intraamniotic infection and from 52 uninfected matched control women and cultured quantitatively for anaerobes and aerobes.
Obstetrics and GynecologyPreterm Labor Associated With Subclinical Amniotic Fluid Infection and With Bacterial Vaginosis
461 Citations1986Michael G. Gravett, Deborah Hummel +2 more
The data underscore the importance of amniotic fluid bacterial infections in preterm labor and premature delivery, and suggest that bacterial vaginosis is associated with prematurity.
American Journal of Obstetrics and GynecologyIntraamniotic infection and the onset of labor in preterm premature rupture of the membranes
372 Citations1988Roberto Romero, Rubén A. Quintero +5 more
The results provide a basis for the clinical impression that the onset of labor in women with preterm premature rupture of the membranes is associated with a subclinical intraamniotic infection.
PubMedChorioamnionitis in the preterm gestation.
288 Citations1982Thomas J. Garite, Roger K. Freeman
Neither trial of labor nor duration of labor in patients with chorioamnionitis correlated with adverse neonatal outcome, however, the appearance of maternal fever prior to the onset of labor correlated more significantly with neonatal death and RDS in the newborn than did the development of maternal Fever in the intrapartum period.
The LancetCAUSES AND CONSEQUENCES OF PREMATURE RUPTURE OF FETAL MEMBRANES
226 Citations1980RichardL. Naeye, EllenC. Peters
There was no relation between the frequency of premature rupture and the number of coital acts in the month before delivery but at every gestational age the proportion of fetuses and neonates who died with amniotic-fluid infections was greater when coitus had occurred in the week before delivery.
Journal of Clinical MicrobiologyDifferential agar medium (A7) for identification of Ureaplasma urealyticum (human T mycoplasmas) in primary cultures of clinical material
221 Citations1976Maurice C. Shepard, Carl D. Lunceford
A differential agar medium for the identification of Ureaplasma urealyticum in primary cultures of clinical specimens is described and colonies are identified as dark golden-brown or rich deep-brown colonies, in sharp contrast to the light background of the medium, when viewed by direct transmitted illumination under the low power of the microscope.
American Journal of Obstetrics and GynecologyThe value and limitations of the Gram stain examination in the diagnosis of intraamniotic infection
193 Citations1988Roberto Romero, Mohamed Emamian +5 more
Gram stain examination of amniotic fluid is a method used for the rapid diagnosis of intraamniotic infection in patients with preterm premature rupture of membranes and preterm labor and patients with a false negative Gram stain had a 25% incidence of neonatal infectious complications (proved and suspected sepsis).
American Journal of Obstetrics and GynecologyLabor and infection
190 Citations1988Roberto Romero, P F Roslansky +6 more
The detection of endotoxin in the amniotic fluid of patients with gram-negative intraamniotic infection and premature rupture of membranes using a computer-assisted quantification of the turbidimetric reaction between the Limulus amebocyte lysate and endotoxin was reported.
American Journal of Obstetrics and GynecologyManagement of acute chorioamnionitis
189 Citations1980Ronald S. Gibbs, Maria Castillo +1 more
Maternal outcome was usually good following vaginal delivery and more complicated following abdominal delivery, and over 90% of patients were delivered within 12 hours of diagnosis of chorioamnionitis.
American Journal of Obstetrics and GynecologyAmniotic fluid infection as determined by transabdominal amniocentesis in patients with intact membranes in premature labor
157 Citations1981J.R. Bobitt, Clifford C. Hayslip +1 more
The data suggest that the presence of microorganisms in the amniotic fluid of afebrile patients in premature labor with intact membranes represents an infectious process rather than an innocuous condition and raises questions with regard to current obstetric trends in the management of premature labor.
PubMedThe use of amniocentesis in patients with premature rupture of membranes.
153 Citations1979TJ Garite, Freeman Rk +2 more
Amniocentesis appears in this study to be a useful method for selecting the patients who have mature fetuses and/or who are more likely to develop amnionitis.
American Journal of Obstetrics and GynecologyBacterial attachment to the chorioamniotic membranes
150 Citations1984Rudolph P. Galask, Michael W. Varner +2 more
It appeared that group B streptococci had a greater capacity to attach and invade than did E. coli, whereas N. gonorrhoeae predictably failed to attach.
American Journal of Obstetrics and GynecologyIntra-amniotic bacterial colonization in premature labor
131 Citations1984Camille J. Wahbeh, Gale B. Hill +2 more
The greatest impact of intra-amniotic bacterial colonization in premature labor with intact membranes on perinatal outcome is expressed in extreme prematurity and appears to be a function of the pathogenicity and concentration of the offending organism(s).
PubMedUse of amniocentesis in preterm gestation with ruptured membranes.
126 Citations1984David B. Cotton, Lyndon M. Hill +3 more
In infants at less than 32 weeks' gestation, amniocentesis need not be done for pulmonary maturity as the morbidity of prematurity in this group is too high even in the presence of pulmonary maturity.
American Journal of Obstetrics and GynecologySilent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy
121 Citations1984Chaudhry Hameed, Nergesh Tejani +2 more
It is concluded that silent chorioamnionitis is a significant cause of "uncomplicated" preterm labor refractory to conventional methods of tocolysis.
PubMedAmniocentesis for gram stain and culture in preterm premature rupture of the membranes.
114 Citations1985Fredrik F. Broekhuizen, M Gilman +1 more
Amniocentesis for Gram stain and culture has clinical usefulness in preterm PROM and, despite false-positive tests, the authors' data support intervention on the basis of a positive Gram stain.
Journal of Clinical MicrobiologySerological Typing of <i>Ureaplasma urealyticum</i> Isolates from Urethritis Patients by an Agar Growth Inhibition Method
114 Citations1978Maurice C. Shepard, Carl D. Lunceford
A previously unknown association of U. urealyticum with frequently abacteriuric, unexplained pyuria (with or without urethral pruritus and dysuria) is reported, suggesting the existence of asymptomatic Ureaplasma urethritis.
PubMedAmniocentesis and the management of premature labor.
93 Citations1986Jennifer Leigh, Thomas J. Garite
It is concluded that amniocentesis is an important tool in evaluating patients in preterm labor, especially with respect to making appropriate management decisions regarding tocolytic and/or corticosteroid therapy.
PubMedAmniocentesis with premature rupture of membranes.
83 Citations1986Feinstein Sj, AM Vintzileos +4 more
Transabdominal amniocentesis was used in 73 consecutive, referred patients with premature rupture of membranes and no clinical signs of infection or labor and there was no difference in the frequency of neonatal infection, one-minute Apgar score, cord blood pH, or perinatal mortality between the two groups.
PubMedBacterial growth inhibition by amniotic fluid. III. Demonstration of the variability of bacterial growth inhibition by amniotic fluid with a new plate-count technique.
82 Citations1975Patrick M. Schlievert, Bryan Larsen +2 more
The ability of 50 human amniotic fluid samples to inhibit the growth of Escherichia coli was measured with a new semimicro plate-count technique, with a range from bacterial growth-sustaining fluid to bactericidal fluid observed.
PubMedBacteria and inflammatory cells reduce chorioamniotic membrane integrity and tensile strength.
81 Citations1989J N Schoonmaker, D W Lawellin +2 more
The concept that human neutrophils and their constituent enzymes may act in concert with bacteria and their protease(s) in weakening amniochorion, and may possibly predispose to premature rupture of membranes in some women, is supported.
PubMedQualitative amniotic fluid volume versus amniocentesis in predicting infection in preterm premature rupture of the membranes.
75 Citations1986Anthony M. Vintzileos, Winston A. Campbell +4 more
Comparison of these two methods in predicting infection outcome suggests them to have the same efficacy in predicting infections outcome in patients with premature rupture of the membranes.
American Journal of Obstetrics and GynecologyBacterial growth inhibition by amniotic fluid
68 Citations1976Patrick M. Schlievert, William Johnson +1 more
The zinc bacterial inhibitory activity of amniotic fluid is dependent on the presence of a second, organic component contained in amniotics fluid, and this component may be a peptide with a molecular weight of less than 5,000 daltons.
PubMedSubclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor.
64 Citations1987Patrick Duff, Kopelman Jn
In this population, subclinical infection was an uncommon cause of refractory preterm labor and none of the patients developed clinical evidence of intra-amniotic infection or postpartum endometritis.
PubMedAmniocentesis in the evaluation of premature labor.
63 Citations1981Roger L. Wallace, C.Neil Herrick
Based on the results of this study, amniocentesis solely for the confirmation of asymptomatic amnionitis in the patient in premature labor seems to be of questionable value.
Obstetrics and Gynecology Clinics of North AmericaETIOLOGY OF PRETERM PREMATURE RUPTURE OF MEMBRANES
50 Citations1992Phillip J. Shubert, Eleanor Diss +1 more
Evidence continues to support a multifactorial etiology for this entity, with numerous factors acting in concert.
American Journal of Obstetrics and GynecologyBacterial growth inhibition by amniotic fluid
47 Citations1974Bryan Larsen, Irvin S. Snyder +1 more
It has been demonstrated that amniotic fluid fails to support the growth of Escherichia coli, Streptococcus faecalis, and Staphylococcus aureus by measuring bacterial growth spectrophotometrically.
Infection and ImmunityIsolation of a low-molecular-weight antibacterial system from human amniotic fluid
45 Citations1976Patrick M. Schlievert, William Johnson +1 more
Removal of zinc from the peptide has been shown to remove bacterial inhibitory activity and can be inactivated by digestion with carboxypeptidase.
PubMedThe clinical value of gas-liquid chromatography in the detection of intra-amniotic microbial invasion.
36 Citations1988Roberto Romero, Katelyn T Scharf +4 more
Gas-liquid chromatographic analysis of amniotic fluid has limited clinical value in the prediction of amNiotic fluid culture when the Gram stain examination is negative.
PubMedEvaluation of amniotic fluid in preterm labor with intact membranes.
36 Citations1985Weible Dr, Randall Hw
Intrauterine infection may play a lesser role in preterm labor with intact membranes than previously postulated and amniocentesis may provide useful information for directing management by permitting one to assess fetal pulmonary maturity and the presence of meconium.
American Journal of Obstetrics and GynecologyStudies on the antimicrobial activity of amniotic fluid
35 Citations1976John B. Miller, J. Michel +3 more
Amniotic fluid samples from women in their second and third trimesters of pregnancy were examined and the presence of spermine in the fluids accounted for some of the antimicrobial activity.
American Journal of Obstetrics and GynecologyBacterial growth inhibition by amniotic fluid
27 Citations1974Bryan Larsen, Irvin S. Snyder +1 more
It is proposed that phosphate interacts with a bacterial growth inhibitor in amniotic fluid which results in the loss of its bacterial growth-inhibiting ability, and reversal of growth inhibition was demonstrated with various phosphate containing compounds.
BJOG An International Journal of Obstetrics & GynaecologyAntibacterial activity in human amniotic fluid: relationship to zinc and phosphate
24 Citations1984T. M. N. Scane, D. F. Hawkins
Antibacterial activity, tested with B. subtilis, was present in all 44 human amniotic fluids at between 36 and 42 weeks of pregnancy and was unrelated to gestational age within these limits, or to maternal age or parity.
American Journal of Obstetrics and GynecologyFetal immune response following prematurely ruptured membranes
17 Citations1976Lars L. Cederqvist, Linda C. Francis +3 more
The potential importance of IgA determinations in cord blood in addition to IgM determination for detection of intrauterine infections is stressed.
Journal of Obstetrics and GynaecologyIdentification of β-lysin as a zinc-dependent antibacterial protein in amniotic fluid
13 Citations1981Larry C. Ford, W. Kasha +5 more
The antibacterial activity against Escherichia coli was found to be zinc dependent, differed markedly between the two groups, and could be removed by a divalent anion chelating agent, 1,10-phenanthroline.