Improvement in learning associated with increase in hippocampal formation volume
Biological PsychiatryPublished 30 January 2003
Monica N. Starkman, Bruno Giordani, Stephen S. Gebarski, D.E. Schteingart
Citations148
SJR quartileQ1
SJR score4.68
SNIP2.24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
After cortisol levels decline to normal concentrations, structural volumetric increase in HFV is accompanied by functional improvement in learning of unrelated words, which is associated with improvement in cognition.
Abstract
After cortisol levels decline to normal concentrations, structural volumetric increase in HFV is accompanied by functional improvement in learning of unrelated words.
Keywords
MedicineNeuroscience
EndocrinologyTwo Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation
2,563 Citations1985Johannes M. H. M. Reul, E. R. de Kloet
It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target.
Neurobiology of AgingStaging of alzheimer's disease-related neurofibrillary changes
2,373 Citations1995Heiko Braak, Eva Braak
Specific immunocytochemical methods (AT8) permit evaluation of neuronal changes well before the actual formation of neurofibrillary tangles and neuropil threads, which facilitates recognition of even subtle pathologic changes throughout the entire extent of cortical territories such as the transentorhinal and entorHinal regions.
NeurologyEvaluating storage, retention, and retrieval in disordered memory and learning
1,612 Citations1974Herman Buschke, Paula Altman Fuld
These new methods provide simultaneous analysis of storage, retention, and retrieval during verbal learning because they let the patient show learning by spontaneous retrieval without csnfounding by continual presentation.
NeurologyPrediction of AD with MRI-based hippocampal volume in mild cognitive impairment
1,405 Citations1999Clifford R. Jack, Ronald Petersen +8 more
In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.
Biological PsychiatryHippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
835 Citations1992Monica N. Starkman, Stephen S. Gebarski +2 more
An association between reduced HF volume, memory dysfunction, and elevated cortisol in patients with CS is suggested.
Biological PsychiatryEffects of adverse experiences for brain structure and function
639 Citations2000Bruce S. McEwen
It is important to appreciate how hippocampal dysfunction may play a role in the symptoms of the psychiatric illness and, from a therapeutic standpoint, to distinguish between a permanent loss of cells and a reversible remodeling to develop treatment strategies to prevent or reverse deficits.
Behavioral NeuroscienceWorking memory is more sensitive than declarative memory to the acute effects of corticosteroids: A dose-response study in humans.
506 Citations1999Sonia Lupien, Christian J. Gillin +1 more
Biological PsychiatryDecrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease
454 Citations1999Monica N. Starkman, Bruno Giordani +4 more
Changes in human HFV associated with sustained hypercortisolemia are reversible, at least in part, once cortisol levels decrease, and the human hippocampus exhibits increased sensitivity to cortisol, affecting both volume loss and recovery.
Neurobiology of AgingFrequency of hippocampal formation atrophy in normal aging and Alzheimer's disease
429 Citations1997Mony J. de Leon, Ajax E. George +14 more
The results of the present study indicate that hippocampal formation atrophy is associated with memory and cognitive impairments and further longitudinal and neuropathologic work is required to validate the relationship between hippocampal Formation atrophy and AD.
NeurologyMemory and MRI-based hippocampal volumes in aging and AD
423 Citations2000Ronald C. Petersen, Clifford R. Jack +8 more
Archives of General PsychiatryPatterns of Cognitive Decline in Presymptomatic Alzheimer Disease
371 Citations2001Peijun Chen, Graham Ratcliff +4 more
Memory and executive dysfunction showed the greatest decline over time in individuals who would clinically manifest AD 1.5 years later and highlight the importance of executive dysfunction early in the disease process and might facilitate early detection of AD.
Journal of Steroid BiochemistryAnatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis
321 Citations1986Johannes M. H. M. Reul, E. R. de Kloet
In vitro autoradiography revealed that CR receptor sites are almost entirely restricted to the septal-hippocampal complex, whereas the presence of GR extends throughout the brain, and in vitro determination of binding of 3H-labelled steroids to CR and GR in cytosol of "punched out" brain tissue revealed a similar neuroanatomical distribution.
Psychosomatic MedicineDepressed Mood and Other Psychiatric Manifestations of Cushingʼs Syndrome: Relationship to Hormone Levels
289 Citations1981Monica N. Starkman, D.E. Schteingart +1 more
A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level and low ACTH levels were significantly associated with milder rather than pronounced depressed mood.
PubMedMethods for normalization of hippocampal volumes measured with MR.
239 Citations1995S. L. Free, Peter Bergin +4 more
Psychosomatic MedicineElevated Cortisol Levels in Cushing’s Disease Are Associated With Cognitive Decrements
207 Citations2001Monica N. Starkman, Bruno Giordani +3 more
The results suggest that both the neocortex and hippocampus are affected in patients with Cushing’s disease, andVerbal learning and other verbal functions seem more vulnerable than nonverbal functions.
The Journal of Clinical Endocrinology & MetabolismCortisol Reduces Hippocampal Glucose Metabolism in Normal Elderly, but Not in Alzheimer’s Disease*
169 Citations1997Mony J. de Leon, Tom McRae +9 more
The interpretation is offered that glucocorticoid-mediated regulation of glucose transport is altered in AD, and this may underlie both the hippocampal insensitivity to cortisol and the failure in these patients to mount a peripheral glucose response.
Psychiatry ResearchCushing's syndrome after treatment: Changes in cortisol and ACTH levels, and amelioration of the depressive syndrome
155 Citations1986Monica N. Starkman, D.E. Schteingart +1 more
With cortisol decreased to normal levels, continued high ACTH levels did not prevent improvement in depressed mood and the possibility that cortisol may also play a role in the pathogenesis and/or maintenance of the mood disorder in psychiatric patients is discussed.
Archives of NeurologyWechsler Adult Intelligence Scale Performance
137 Citations1984Thomas N. Chase
Most WAIS subtests appeared to evaluate primarily either verbal or visuospatial cognitive functions and either left parasylvian or right posteroparietal cortical activity, which was most closely associated with verbal and performance IQ scores.
The Journal of Nervous and Mental DiseaseNeuropsychological Deficits in Cushing??s Syndrome
127 Citations1980Timothy B. Whelan, D.E. Schteingart +2 more
Performances on the Michigan Neuropsychological Test Battery revealed varying degrees of diffuse bilateral cerebral dysfunction in two thirds of Cushing's syndrome patients, and impairment was more frequent and severe in non verbal visual-ideational and visual memory functions.
Biological PsychiatryHippocampus in Alzheimer’s disease: a 3-year follow-up MRI study
123 Citations2000Mikko P. Laakso, Maarit Lehtovirta +3 more
Serial MRI of the hippocampus did not offer any advantage over a single MRI to support the diagnosis of AD in this study sample, and changes at an individual level were small, and within the accuracy range of the measurements.
Biological PsychiatryEEG sleep in cushing's disease and cushing's syndrome: comparison with patients with major depressive disorder
44 Citations1992James E. Shipley, D.E. Schteingart +5 more
There were substantial similarities in the abnormal polysomnography profiles of patients with CD, AICS, and MDD, and all three patient groups demonstrated poorer sleep continuity, shortened rapid eye movement (REM) latency, and increased first REM period density compared with normal subjects.
