Glaucoma: Systemic Side Effects of Topical Medical Therapy — A Common and under Recognized Problem
Journal of the Royal Society of MedicinePublished 1 October 1994Open access
Paul Diggory, W. Franks
Citations18
SJR quartileQ1
SJR score1.71
SNIP1.79
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Chronic open angle glaucoma is increasingly common with age affecting about 5% of those over 65 and is responsible for 15% of registrations for blindness in this age group.
Keywords
Medicine
American Journal of OphthalmologyAdverse Effects Experienced by Patients Taking Timolol
216 Citations1979Charles D. McMahon, Robert N. Shaffer +2 more
Adverse effects involving one or more organ systems occurred in 38 of 165 patients with various types of glaucoma when timolol was added to their glAUcoma therapy.
American Journal of OphthalmologyPossible Adverse Effects From Topical Ocular 10% Phenylephrine
195 Citations1978Frederick T. Fraunfelder, Arnauld F. Scafidi
Thirty case reports of significant adverse reactions possibly associated with ocular use of 10% phenylephrine as reported to the National Registry of Drug-Induced Ocular Side Effects, Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, Arkansas are reviewed.
PubMedA study of the prevalence of eye disease in the elderly in an English community.
152 Citations1985Jonathan Gibson, A R Rosenthal +1 more
The prevalence rates for the major sight threatening conditions in the elderly were determined: senile cataract 46.1 per cent, senile macular degeneration 41.5 per cent and open angle glaucoma 6.6 per cent.
British Journal of Diseases of the ChestUnderdiagnosis of asthma in the elderly
142 Citations1987Dithi Banerjee, G.S. Lee +2 more
The study emphasizes the importance of routinely performing lung function tests in elderly patients and the use of reversibility tests to identify reversible airways obstruction.
Clinical PharmacokineticsAbsorption of Ocular Timolol1
127 Citations1980Gunnar Alván, Berit Calissendorff +3 more
The absorption of timolol after topical administration to the eye was studied in 11 healthy volunteers and in 5 patients with bilateral open angle glaucoma, and the drug was found in the urine samples from all volunteers andglaucomatous patients.
JAMATimolol-lnduced Bronchospasm in Asthmatic Bronchitis
100 Citations1981Blair Schoene
To investigate the effect of therapeutic doses of timolol ophthalmic solution on airflow in patients with reversible airflow obstruction, changes in air-flow after administration are studied.
American Journal of OphthalmologyA Double-Masked Comparison of Betaxolol vs Timolol in the Treatment of Open-Angle Glaucoma
95 Citations1986Robert C. Allen, Ellen Hertzmark +2 more
Betaxolol appears to be a clinically effective and safe agent in the treatment of open-angle glaucoma, however, the magnitude of the decrease in intraocular pressure with it may not be as great as that with timolol and there may be a greater need for adjunctive therapy with it than with Timolol.
Archives of OphthalmologyDipivefrin and Epinephrine Treatment of Elevated Intraocular Pressure
58 Citations1979Michael A. Kass
Archives of OphthalmologyArgon Laser Trabeculoplasty Controls One Third of Cases of Progressive, Uncontrolled, Open Angle Glaucoma for 5 Years
55 Citations1992G. L. Spaeth
Seventy-eight patients with progressive glaucoma had argon laser trabeculoplasty as a substitute for filtration surgery and were followed up for a minimum of 5 years, with a failure rate of approximately eight per year.
Age and AgeingUnsuspected Bronchospasm in Association with Topical Timolola Common Problem in Elderly People: Can We easily identify Those affected and do Cardioselective Agents lead to Improvement?
42 Citations1994Paul Diggory, Peter Heyworth +3 more
The presence of exertional dyspnoea, cough with sputum, raised dysPNoea score and improved lung function tests after salbutamol identified those patients experiencing clinically significant bronchospasm with an 89% specificity and 74% sensitivity.
ThoraxChronic respiratory disease in the elderly: A population study
28 Citations1972F. I. Caird, A Akhtar
Chronic bronchitis was a contributory cause of disabling dyspnoea and recurrent chest illness in half of the subjects with these symptoms, and significant radiological evidence of tuberculosis was found in 9% of men and in 4% of women.
Journal of Neurology Neurosurgery & PsychiatryMental status changes induced by eye drops in dementia of the Alzheimer type.
24 Citations1987P. F. Reyes, Bridget Dwyer +2 more
It is felt confident that temporal lobe epilepsy was the primary cause of his asystolic episodes, and that only the subsequent loss of consciousness and jerking could have been attributable to cardiac-induced cerebral ischaemia.
Drugsβ-Blockade and the Human Central Nervous System
14 Citations1983Paul Turner
β-Adrenoceptor blocking drugs, although initially developed to treat ischaemic heart disease, have found their way into other therapeutic areas such as psychiatry and neurology.