A Major Metabolite of Arginine Vasopressin in the Brain Is a Highly Potent Neuropeptide
SciencePublished 23 September 1983
J. Peter H. Burbach, Gábor L. Kovaćs, D. de Wied, J. W. VAN NISPEN, H. M. Greven
Citations263
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A peptide that accumulated as the major product during the proteolysis of arginine vasopressin by rat brain synaptic membranes was isolated and its structure was shown to be the hexapeptide pGlu-Asn-Cys-Pro-Arg-Gly-NH2.
Abstract
A peptide that accumulated as the major product during the proteolysis of arginine vasopressin by rat brain synaptic membranes was isolated and its structure was shown to be the hexapeptide pGlu-Asn-Cys(Cys)-Pro-Arg-Gly-NH2. When administered intracerebroventricularly in extremely low doses, this vasopressin fragment and its desglycinamide derivative facilitated memory consolidation in a passive avoidance situation. These vasopressin metabolites, which are devoid of pressor activity, constitute highly potent neuropeptides with selective effects on memory and related processes; they are activated via proteolytic processing of vasopressin by brain peptidases.
Keywords
Psychology
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