Reversibility of acute intermediate phase bilirubin encephalopathy
Acta PaediatricaPublished 7 July 2009
Thor Willy Ruud Hansen, Lutz Nietsch, Elisabeth Norman, Jesper Vandborg Bjerre, J.-M. Hascoët, Khalaf Mreihil
Citations69
SJR quartileQ1
SJR score0.78
SNIP0.90
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TL;DR
The objective is to show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy with the aim of correcting the underlying cause of encephalopathies.
Abstract
AIM: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. METHODS: Case studies. RESULTS: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal. CONCLUSIONS: Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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