Does vitamin C reduce blood pressure?Results of a large study of people aged 65 or older
Journal of HypertensionPublished 1 July 1998
Christopher J. Bates, Catherine M. Walmsley, Ann Prentice, Steven Finch
Citations78
SJR quartileQ1
SJR score1.10
SNIP1.63
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Plasma ascorbate concentration and intake of vitamin C are covariates of blood pressure in older people living in Britain and are correlated to systolic and diastolic blood pressures and pulse rate.
Abstract
Plasma ascorbate concentration and intake of vitamin C are covariates of blood pressure in older people living in Britain. New intervention studies are now needed, to test for possible causalities.
Keywords
MedicineNursing
The American Journal of CardiologySystolic versus diastolic blood pressure and risk of coronary heart disease
923 Citations1971William B. Kannel, Tavia Gordon +1 more
ScienceBlood Pressure and Nutrient Intake in the United States
690 Citations1984David A. McCarron, Cynthia D. Morris +2 more
Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension, and Increments of dietary calcium were also negatively correlated with body mass.
CirculationNitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.
520 Citations1994Jonathan S. Stamler, Evan Loh +3 more
It is demonstrated that basal release of endothelium-derived NO is directly involved in the determination of systemic vascular resistance and, therefore, blood pressure in healthy humans and NO regulates basal normoxic pulmonary vascular tone.
New England Journal of MedicineCumulative Effects of High Cholesterol Levels, High Blood Pressure, and Cigarette Smoking on Carotid Stenosis
323 Citations1997Peter W.F. Wilson, Jeffrey M. Hoeg +6 more
Over the long term, high systolic blood pressure, high cholesterol levels, and smoking were associated with an increased risk of carotid stenosis in this elderly population.
American Journal of Clinical NutritionRelationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study
323 Citations1987Michel R. Joffres, Dwayne Reed +1 more
Results suggest that foods such as vegetables, fruits, whole grains, and low-fat dairy items are major sources of nutrients that may be protective against hypertension.
BMJVitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people
307 Citations1995Catharine R. Galé, C N Martyn +2 more
In elderly people vitamin C concentration, whether measured by dietary intake or plasma concentration of ascorbic acid, is strongly related to subsequent risk of death from stroke but not from coronary heart disease.
American Journal of Clinical NutritionIncreased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C
304 Citations1993K.F. Gey, UK Moser +4 more
Previous prudent regimens may now be updated, aiming at an optimal status of all essential and synergistically linked antioxidants, independently of classical IHD risk factors.
Journal of the American College of NutritionVitamin C and Cardiovascular Disease: A Review
215 Citations1992Joel A. Simon
Analysis of the literature regarding groups at high risk for coronary heart disease reveals that men, the elderly, smokers, diabetics, hypertensives and perhaps oral estrogen-containing contraceptive users have lowered plasma vitamin C levels.
DiabetesA High-performance Liquid Chromatography Method for Hemoglobin A1c
195 Citations1978James E. Davis, Jay M. McDonald +1 more
A sample-preparation technique using filtration was developed that shortened and simplified preparation of venous blood and allowed use of capillary samples, and can facilitate large-scale clinical investigations and permit biochemical investigations of the metabolism and formation of hemoglobin A1c.
American Journal of Clinical NutritionBlood pressure, dietary fats, and antioxidants
161 Citations1988T Salonen, Riitta Salonen +6 more
The marked elevation of blood pressure at the lowest levels of plasma ascorbic acid and serum Se concentrations supports the hypothesis that antioxidants play a role in the etiology of hypertension.
The Journal of Nutritional BiochemistryTen-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk
141 Citations1995K.F. Gey
In male Americans, the relative risk of cardiovascular diseases was substantially reduced by daily intake of >130 mg of vitamin C, >100 IU of vitamin E, and by >9 mg of β-carotene, but only in smokers—in comparison with a suboptimal intake that very probably permits only sub optimal plasma levels.
American Journal of Clinical NutritionPlasma ascorbic acid concentrations relate inversely to blood pressure in human subjects
131 Citations1993J. Serpa Morán, Lionel Cohen +5 more
This study relates antioxidant status and blood pressure (BP) in 168 healthy residents of Augusta, GA, following usual diets to male gender, body mass index, body fat distribution, plasma cholesterol, low density lipoprotein cholesterol, and triglycerides correlated.
British Journal Of NutritionDiet and incident ischaemic heart disease: the Caerphilly Study
130 Citations1993A M Fehily, J. W. G. Yarnell +2 more
American Journal of Clinical NutritionVitamin C and cardiovascular risk factors
87 Citations1991DL Trout
In a placebo-controlled, double-blinded study, extra ascorbic acid for 6 wk was observed to lower systolic and pulse pressure in a small group of borderline hypertensive subjects.
EpidemiologyDo Nutritional Supplements Lower the Risk of Stroke or Hypertension?
77 Citations1998Steven D. Mark, Wen Wang +8 more
These findings contrast with the larger reductions in stroke death and hypertension found in a parallel trial of Linxian subjects with esophageal dysplasia who received a multivitamin/mineral supplement, suggesting an effect largely derived from nutrients other than those received in the present study.
GerontologyA Double-Blind, Placebo-Controlled Parallel Trial of Vitamin C Treatment in Elderly Patients with Hypertension
74 Citations2009Sanjoy Ghosh, E.B. Ekpo +4 more
No statistical difference between the effects of either vitamin C or placebo treatment on blood pressure was observed and plasma ascorbic acid concentrations were lower in the vitamin C-treated group compared with the placebo group.
Journal of HypertensionVitamin C status and blood pressure
67 Citations1996Andrew R. Ness, Kay‐Tee Khaw +2 more
The plasma vitamin C level may be a marker of other factors; nevertheless, these results are consistent with other published work indicating that a high intake of vitamin C from food confers protection against raised blood pressure and strokes.
PubMedInverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years.
61 Citations1984Masako Yoshioka, Taku Matsushita +1 more
Serum ascorbic acid had an inverse and the strongest association with systolic blood pressure among the risk factors including blood pressure, total cholesterol, triglyceride, gamma-GTP and obesity, and the association was independent of the other variables tested.
PubMedEffects of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats (SH rats).
47 Citations1985Masato Yoshioka, Koji Aoyama +1 more
The abnormalities of ascorbic acid metabolism in the SH rats may be associated with, in part, their high blood pressure, because exogenous ascorBic acid prevented the blood pressure elevation of SH rats, but some other mechanism may also be involved in the effect of asCorbic Acid on blood pressure.
Nutrition ResearchBlood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults
44 Citations1991Odutola Osilesi, David L. Trout +2 more
It appears that vitamin C supplementation may have therapeutic value in human hypertensive disease.
Journal of Clinical EpidemiologyAn investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using discriminant analysis
18 Citations1995Susan Todd, Mark Woodward +2 more
Dietary antioxidant vitamins appear to have a significant effect on the prevalence of CHD, especially amongst men, and the benefits and problems of using discriminant analysis in this practical context are discussed.
PubMedEffect of exogenous ascorbic acid on experimental hypertension and mineral balance in rats fed low- and high-fat diets.
12 Citations1992Ś Ziemlański, M Wartanowicz +5 more
The results showed that the amount of fat, NaCl, and ascorbate in the diet may play a role in the etiopathogenesis of hypertension and Supplementation with asCorbate diminished urine calcium output with a high-fat diet and increased the urine PGE2/PGF2 ratio with both low- and high- Fat diets.
