Ecstasy: A common cause of severe acute hepatotoxicity
Journal of HepatologyPublished 1 September 1998
Victòria Andreu, Antoni Mas, Miquel Bruguera, Joan Manuel Salmerón, Vicente Moreno, Santiago Nogué
Citations183
SJR quartileQ1
SJR score10.57
SNIP6.25
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TL;DR
Ecstasy is responsible for a relatively high number of cases of acute liver failure in young people, and the use of this drug should be investigated in all patients with severe hepatitis of unclear origin.
Abstract
Ecstasy is responsible for a relatively high number of cases of acute liver failure in young people. Therefore, the use of this drug should be investigated in all patients with severe hepatitis of unclear origin. Efforts must be made to advise young people of the risks of ecstasy consumption.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
The LancetToxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
736 Citations1992J.A. Henry, K.J. Jeffreys +1 more
The risk of adverse reactions to 3,4-methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy", is now widely known in both the USA and UK, but the patterns of illness remain varied.
Journal of Clinical PathologyPathology of deaths associated with "ecstasy" and "eve" misuse.
275 Citations1996Christopher M. Milroy, Jenny Clark +1 more
The data suggest that there is more than one mechanism of damage in ring substituted amphetamine misuse, injury being caused by hyperthermia in some cases, but with ring substituted Amphetamines also possibly having a toxic effect on the liver and other organs in the absence ofhyperthermia.
JAMAMultiple Severe Complications From Recreational Ingestion of MDMA ('Ecstasy')
168 Citations1987Christopher R. Brown
A young woman who suffered serious but reversible toxic reactions from a recreational dose of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and whose blood levels of MDMA were much higher than in any of the fatalities reported by Dowling et al.
British Journal of PharmacologyThe hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
165 Citations1995M. Isabel Colado, Jodi L. Williams +1 more
These data demonstrate that female DA rats are more susceptible to the acute hyperthermic effects of MDMA, probably because of impaired N‐demethylation and indicate that in human subjects acute MDMA‐induced toxicity may be exacerbated in poor metabolizer phenotypes.
GutAcute liver damage and ecstasy ingestion.
163 Citations1996A J Ellis, Julia Wendon +2 more
Patients developing jaundice or with evidence of hepatic failure particularly encephalopathy and prolongation of the international normalised ratio, or both, whether or not preceded by hyperthermia, should be referred to a specialised liver unit as liver transplantation probably provides the only chance of recovery.
GutEcstasy induced hepatitis mimicking viral hepatitis.
78 Citations1995R S Dykhuizen, P W Brunt +3 more
Three cases of jaundice after ingestion of 3,4-methylenedioxymetamphetamine (MDMA), known as 'ecstasy', are reported and the complications associated with the misuse of this drug, which was initially misrepresented as 'safer than alcohol' are described.
GastroenterologyLiver transplantation for acute liver failure: Analysis of applicability
73 Citations1993Antoni Castells, Joan Manuel Salmerón +6 more
Considering the high survival rate obtained in the patients with transplantations and the poor survival rate observed in those who could not be transplanted, efforts should be made to increase liver transplant applicability to improve the prognosis in acute liver failure.
Journal of Clinical GastroenterologyHepatotoxicity and Accelerated Fibrosis Following 3,4-Methylenedioxymetamphetamine (“Ecstasy”) Usage
57 Citations1995Salim I. Khakoo, Christopher Coles +2 more
This work presents the first recorded case of ecstasy-induced accelerated hepatic fibrosis, a case of acute hepatitis reported to cause an acute hepatitis that may progress to liver failure.
Journal of HepatologyChronic ecstasy (3,4-methylenedioxymetamphetamine) abuse: a recurrent and unpredictable cause of severe acute hepatitis
51 Citations1996Helen Fidler, Amar P. Dhillon +2 more
A high index of suspicion and careful specific enquiry are necessary to make the diagnosis and warn the patient to abstain in future, since subsequent attacks may be fatal and insidious chronic damage may occur.
Transplant InternationalLiver transplantation for the treatment of fulminant hepatic failure induced by the ingestion of ecstasy
46 Citations1997Robert Brauer, CD Heidecke +7 more
MDMA, more commonly known as ecstasy, is a synthetic amphetamine derivative used by teenagers and young adults in the United States as well as in Western Europe as a “dance drug”.
Transplant InternationalLiver transplantation for the treatment of fulminant hepatic failure induced by the ingestion of ecstasy
39 Citations1997Robert Brauer, CD Heidecke +7 more
Liver InternationalRecurrent liver involvement in heatstroke
30 Citations1996Pau Sort, Antoni Mas +3 more
The case of a young patient who presented two self-limited episodes of acute jaundice that developed immediately following a long distance run seems to be the first case of severe and recurrent liver impairment due to heatstroke.
PubMed[Epidemiology of designer drug use in Spain].
17 Citations1997de la Fuente de Hoz L, M. Ángeles Rodríguez-Arenas +3 more
The occasional use of different design drugs has spread to some degree among young people, varies considerably by geographic region, and is associated with the use of other legal and illegal substances, specially stimulants.