Trichodermin resistance—mutation affecting eukaryotic ribosomes
NaturePublished 1 April 1974
Daniel Schindler, P G Grant, Julian Davies
Citations71
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Genetic information on the translation apparatus in eukaryotes has come mainly from studies of temperature-sensitive mutants, and also cycloheximide resistance, which is known to be a property of the 60S subunit.
Abstract
GENETIC studies of ribosomes in prokaryotes such as Escherichia coli have been facilitated by the use of mutants resistant to antibiotics; mutations which affect either subunit of the ribosome are known1. In eukaryotes, genetic information on the translation apparatus has come mainly from studies of temperature-sensitive mutants2,10, and also cycloheximide resistance, which is known to be a property of the 60S subunit3. Recent studies with resistance to the alkaloid cryptopleurine have shown that Saccharomyces cerevisiae strains resistant to this compound have altered ribosomes4.
Keywords
Biochemistry, Genetics and Molecular BiologyEnvironmental Science
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