Active and Inactive Protein Kinases: Structural Basis for Regulation
CellPublished 1 April 1996Open access
L.N. Johnson, M.E.M. Noble, David J. Owen
Citations1,403
SJR quartileQ1
SJR score22.61
SNIP7.62
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TL;DR
This review summarizes the current understand of the crystal structure Control mechanisms that have been recognized to determination of cAPK and showed the structural importance of Thr-197 or domains that may function in response to second phosphorylation and demonstrated possible roles of messengers.
Abstract
Protein kinases and phosphatases play pivotal roles in regulating and coordinating aspects of metabolism, gene expression, cell growth, cell motility, cell differentiation, and cell division. As a result, if cellular life is to function in an orderly manner, the switching on and off of protein kinases and phosphatases is as crucial for their function as their catalytic activity.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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