Correction of non–24‐hour sleep/wake cycle by melatonin in a blind retarded boy
Annals of NeurologyPublished 1 March 1991
Lars Palm, Gösta Blennow, Lennart Wetterberg
Citations146
SJR quartileQ1
SJR score3.74
SNIP2.26
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TL;DR
Melatonin convincingly entrained the endogenous rhythm to the appropriate chronological 24‐hour day in this 9‐year‐old, blind boy with severe mental retardation with a chronic sleep/wake disturbance.
Abstract
A 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24.75 hours and an internal desynchronization of the endogenous rhythms. Treatment with oral melatonin given at 6 PM induced a regular sleep/wake pattern. Melatonin, in this patient, convincingly entrained the endogenous rhythm to the appropriate chronological 24-hour day.
Keywords
PsychologyNeuroscience
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