Regulation of Protein Synthesis in HeLa Cells
Journal of VirologyPublished 1 November 1971Open access
Robert D. Leibowitz, Sheldon Penman
Citations119
SJR quartileQ1
SJR score1.28
SNIP0.90
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TL;DR
The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of hostpolyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA).
Abstract
The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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