Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition
Biological PsychiatryPublished 30 January 2004
Robert D. Rogers, Narender Ramnani, Clare E. Mackay, James L. Wilson, Peter Jezzard, Cameron S. Carter
Citations401
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Neural activity within the medial and lateral orbitofrontal cortex, pregenual ACC, and striatum mediate distinct representations of reward-related information that are deployed at different stages during a decision-making episode.
Abstract
Neural activity within the medial and lateral orbitofrontal cortex, pregenual ACC, and striatum mediate distinct representations of reward-related information that are deployed at different stages during a decision-making episode.
Keywords
Neuroscience
EconometricaProspect Theory: An Analysis of Decision under Risk
47,019 Citations1979Daniel Kahneman, Amos Tversky
Cambridge University Press eBooksProspect theory: An analysis of decision under risk
33,002 Citations1988Daniel Kahneman, Amos Tversky
NeuroImageImproved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images
10,645 Citations2002Mark Jenkinson
NeuroImageImproved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images
9,613 Citations2002Mark Jenkinson, Peter Bannister +2 more
This paper examines the optimization process in detail and demonstrates that the commonly used multiresolution local optimization methods can, and do, get trapped in local minima.
Journal of the Royal Statistical Society Series D (The Statistician)Statistical Methods for Psychology.
8,377 Citations1994Andrew C. Gudgeon, David C. Howell
Psychological ReviewConflict monitoring and cognitive control.
7,129 Citations2001Matthew Botvinick, Todd S. Braver +3 more
Two computational modeling studies are reported, serving to articulate the conflict monitoring hypothesis and examine its implications, including a feedback loop connecting conflict monitoring to cognitive control, and a number of important behavioral phenomena.
Trends in Cognitive SciencesCognitive and emotional influences in anterior cingulate cortex
6,248 Citations2000George Bush, George Bush +4 more
Various findings are reviewed in relation to the idea that ACC is a part of a circuit involved in a form of attention that serves to regulate both cognitive and emotional processing, and how the success of this regulation in controlling responses might be correlated with cingulate size.
NeuroImageFunctional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI
3,490 Citations2002K. Luan Phan, Tor D. Wager +2 more
A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.
BrainContributions of anterior cingulate cortex to behaviour
3,356 Citations1995Orrin Devinsky, Martha J. Morrell +1 more
The cingulate epilepsy syndrome provides important support of experimental animal and human functional imaging studies for the role of anterior cingulates cortex in movement, affect and social behaviours.
Magnetic Resonance in MedicineImproved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold
3,234 Citations1995Steven D. Forman, Jonathan D. Cohen +4 more
Monte Carlo simulations and fMRI studies of human subjects have been used to verify that this approach can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.
Proceedings of the National Academy of SciencesMedial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
3,035 Citations2001Debra A. Gusnard, Erbil Akbudak +2 more
The presence of self-referential mental activity appears to be associated with increases from the baseline in dorsal MPFC, and reductions in ventral MPFC occurred consistent with the fact that attention-demanding tasks attenuate emotional processing.
NeuroImageTemporal Autocorrelation in Univariate Linear Modeling of FMRI Data
3,024 Citations2001Mark W. Woolrich, B. D. Ripley +2 more
Estimation is improved by using nonlinear spatial filtering to smooth the estimated autocorrelation, but only within tissue type, and reduced bias to close to zero at probability levels as low as 1 x 10(-5).
NatureSubgenual prefrontal cortex abnormalities in mood disorders
2,701 Citations1997Wayne C. Drevets, Joseph L. Price +5 more
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Cerebral CortexThe Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans
2,636 Citations2000Döst Öngür
The OMPFC appears to function as a sensory-visceromotor link, especially for eating, which appears to be critical for the guidance of reward-related behavior and for setting of mood.
Progress in NeurobiologyFrom motivation to action: Functional interface between the limbic system and the motor system
2,341 Citations1980Gordon J. Mogenson, Douglas L. Jones +1 more
It has been proposed that the nucleus accumbens is a key component of this neural interface since it receives inputs from limbic forebrain structures, either directly or indirectly via the ventral tegmental area of Tsai, and sends signals to the motor system via the globus pallidus.
Journal of NeuroscienceAnticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
2,234 Citations2001Brian Knutson, Charles M. Adams +2 more
Findings suggest that whereas other striatal areas may code for expected incentive magnitude, a region in the NAcc codes for expected positive incentive value, which is correlated with individual differences in self-reported happiness elicited by the reward cues.
Neuroscience & Biobehavioral ReviewsEmotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
2,110 Citations2002Rudolf N. Cardinal, John A. Parkinson +2 more
The basolateral amygdala (BLA) appears to be required for a Pavlovian conditioned stimulus to gain access to the current value of the specific unconditioned stimulus (US) that it predicts, while the central nucleus of the amygdala acts as a controller of brainstem arousal and response systems, and subserves some forms of stimulus-response Pavlovia conditioning.
Journal of Cerebral Blood Flow & MetabolismA Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain
2,055 Citations1992Keith J. Worsley, Alan C. Evans +2 more
A simple method for determining an approximate p value for the global maximum based on the theory of Gaussian random fields is described, which focuses on the Euler characteristic of the set of voxels with a value larger than a given threshold.
Nature NeuroscienceAbstract reward and punishment representations in the human orbitofrontal cortex
2,031 Citations2001John P. O’Doherty, Morten L. Kringelbach +3 more
Findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.
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2,004 Citations1999Antoine Bechara, Hanna Damásio +2 more
The results suggest that amygdala damage is associated with impairment in decision-making and that the roles played by the amygdala and VMF in decision -making are different.
Human Brain MappingAssessing the significance of focal activations using their spatial extent
1,948 Citations1994Karl Friston, Keith J. Worsley +3 more
The results mean that detecting significant activations no longer depends on a fixed threshold, but can be effected at any (lower) threshold, in terms of the spatial extent of the activated region.
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This work introduces to neuroimage modelling the approach of reference priors, which drives the choice of prior such that it is noninformative in an information-theoretic sense, and proposes two inference techniques at the top level for multilevel hierarchies.
Cerebral CortexMotor Areas of the Medial Wall: A Review of Their Location and Functional Activation
1,711 Citations1996Nathalie Picard, Peter L. Strick
The analysis suggests that it is possible to identify at least four separate cortical areas on the medial wall of the hemisphere, which appear to be analogous to the pre-SMA, the SMA proper, and two of the cingulate motor areas of the monkey.
NeuronFunctional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses
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The overlap of the observed activations with those seen previously in response to tactile stimuli, gustatory stimuli, and euphoria-inducing drugs is consistent with a contribution of common circuitry to the processing of diverse rewards.
NatureRelative reward preference in primate orbitofrontal cortex
1,339 Citations1999Léon Tremblay, Wolfram Schultz
Neurons in the orbitofrontal cortex of monkeys process the motivational value of rewarding outcomes of voluntary action, mainly irrespective of the spatial and visual features of reward-predicting stimuli and behavioural reactions.
NeuroImageMovement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional Movement Patterns
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1,178 Citations1996Antoine Bechara, Daniel Tranel +2 more
A physiological correlate for the defect of prefrontal damage is identified and its possible significance is discussed, compatible with the idea that these patients fail to activate biasing signals that would serve as value markers in the distinction between choices with good or bad future outcomes.
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1,116 Citations1999Robert D. Rogers
It is suggested that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC, which may reflect altered neuromodulation of the orbitof prefrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine projections.
Proceedings of the National Academy of SciencesDorsal anterior cingulate cortex: A role in reward-based decision making
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Journal of NeuroscienceDissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex
1,056 Citations1998Antoine Bechara, Hanna Damásio +2 more
A cognitive and anatomic double dissociation between deficits in decision making (anterior VM) and working memory (right DL/M) is revealed, the first direct evidence of such effects in humans using the lesion method and underscores the special importance of the VM prefrontal region in decisionMaking, independent of a direct role in working memory.
The Journal of Comparative NeurologyArchitectonic subdivision of the human orbital and medial prefrontal cortex
953 Citations2003Döst Öngür, Amon T. Ferry +1 more
The structure of the human orbital and medial prefrontal cortex (OMPFC) was investigated using five histological and immunohistochemical stains and was correlated with a previous analysis in macaque monkeys.
The Journal of Comparative NeurologyArchitecture and intrinsic connections of the prefrontal cortex in the rhesus monkey
953 Citations1989Helen Barbas, Deepak Ν. Pandya
An investigation of the architectonic organization and intrinsic connections of the prefrontal cortex was conducted in rhesus monkeys and reveals that the limbic areas are poorly myelinated, adjacent areas have a diffuse myelin content confined to the deep layers, and in isocortices theMyelinated fibers are distributed in organized horizontal bands (of Baillarger and a vertical plexus.
NeuroImageA region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
859 Citations2003Brian Knutson, Grace Fong +3 more
In the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes, as indicated by volume-of-interest analyses.
NeuropsychologiaNeuroanatomical correlates of pleasant and unpleasant emotion
817 Citations1997Richard D. Lane, Eric M. Reiman +5 more
There are both common and unique components of the neural networks mediating pleasant and unpleasant emotion in healthy women that are consistent with those from other recent PET studies of human emotion.
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The results suggest that areas implicated in emotion and attention are differentially involved in generation and representation of peripheral SCR responses, and propose that this functional arrangement enables integration of adaptive bodily responses with ongoing emotional and attentional states of the organism.
PubMedChoosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex.
766 Citations1999Robert D. Rogers, A. M. Owen +5 more
The results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.
American Journal of PsychiatryNeuroanatomical correlates of happiness, sadness, and disgust
758 Citations1997Richard D. Lane, Eric M. Reiman +3 more
This study identifies regions of the brain that participate in happiness, sadness, and disgust, regions that distinguish between positive and negative emotions, and regions that depend on both the elicitor and valence of emotion or their interaction.
The Journal of Comparative NeurologyHuman cingulate cortex: Surface features, flat maps, and cytoarchitecture
751 Citations1995Brent A. Vogt, Esther A. Nimchinsky +2 more
The surface morphology and cytoarchitecture of human cingulate cortex was evaluated in the brains of 27 neurologically intact individuals to provide structural underpinnings for interpreting functional imaging studies of the human medial surface.
Journal of NeuroscienceChoosing between Small, Likely Rewards and Large, Unlikely Rewards Activates Inferior and Orbital Prefrontal Cortex
748 Citations1999Robert D. Rogers, Adrian M. Owen +5 more
Journal of NeuroscienceDissociable Neural Responses in Human Reward Systems
741 Citations2000Rebecca Elliott, Karl Friston +1 more
Functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts and demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties.
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647 Citations1998Paul J. Whalen, George Bush +5 more
The ecStroop will be a useful fMRI probe of ACad function in anxiety disorders and offer a within-group spatial dissociation of AC function based upon information content (i.e., cognitive vs. emotional) and/or presence of behavioral interference.
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609 Citations1996S. Thomas Carmichael, J.L. Price
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As monkeys perform schedules containing several trials with a visual cue indicating reward proximity, their error rates decrease as the number of remaining trials decreases, suggesting that their motivation and/or reward expectancy increases as the reward approaches.
NeuroreportRegional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex
460 Citations1998Tomáš Paus, Lisa Koski +2 more
It is concluded that task difficulty plays a major role in modulating blood-flow response in the ACC, possibly interacting with other parameters such as the nature of the response and memory demands.
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