Treatment of Severe Hypertension with Methyldopa
BMJPublished 19 January 1963Open access
M. Hamilton, H. Kopelman
Citations53
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
There are patients who with methyldopa have unmistakable degrees of postural hypotension and others who exhibit practically none, and doses up to 2 g.
Keywords
Medicine
ScienceDecarboxylase Inhibition and Blood Pressure Reduction by α-Methyl-3,4-Dihydroxy-DL-phenylalanine
257 Citations1960John A. Oates, Louis J. Gillespie +2 more
α-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man and decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids.
Archives of Biochemistry and BiophysicsInhibition of dihydroxyphenylalanine decarboxylase by derivatives of phenylalanine
223 Citations1954Theodore L. Sourkes
A series of compounds, related chemically to phenylalanine, have been examined for their action on dopa decarboxylase of pig kidney and on bacterial tyrosine decar boxylase, and some of the compounds were found to inhibit these enzymes.
CirculationClinical and Chemical Studies with <i>α</i> -Methyl-Dopa in Patients with Hypertension
145 Citations1962Louis J. Gillespie, John A. Oates +2 more
From observations to date the impression has been gained that Aldomet has several advantages over other antihypertensive agents; these include effectiveness against all degrees of hypertension, frequent lowering of recumbent as well as standing blood pressure, smoothness of effect, and tranquilizing effects.
New England Journal of MedicineSerotonin Synthesis in Carcinoid Patients
73 Citations1960Albert Sjoerdsma, John A. Oates +2 more
BMJAnother Hypotensive Agent—Methyldopa
24 Citations1962Denis Daley, Byron Evans
An adequate layer of silicone on the skin is probably more economically obtained by using 100% silicone, for it is more easily seen and the silicone in alcohol tends to run off the patient's back during spraying, carrying the silicone to areas where it is not required.