The <i>Arabidopsis</i> Circadian Clock Incorporates a cADPR-Based Feedback Loop
SciencePublished 15 November 2007
Antony N. Dodd, Michael Gardner, Carlos Takeshi Hotta, Katharine Hubbard, Neil Dalchau, John Love
Citations217
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
It is shown that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR), which modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release.
Abstract
Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
Keywords
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