Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease
Journal of Neurology Neurosurgery & PsychiatryPublished 18 November 2002Open access
Serge A.R.B. Rombouts
Citations158
SJR quartileQ1
SJR score3.38
SNIP2.41
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TL;DR
Evidence is provided that in mild Alzheimer’s disease, rivastigmine enhances brain activation in the fusiform and frontal cortices, which is compatible with the concept of cholinergic circuitry.
Abstract
These findings link the previously observed increase in cognitive performance in Alzheimer's disease after treatment with a cholinesterase inhibitor to altered brain activation. Although the results cannot be generalised to the Alzheimer's disease population at large, they provide evidence that in mild Alzheimer's disease, rivastigmine enhances brain activation in the fusiform and frontal cortices. This is compatible with the concept of cholinergic circuitry.
Keywords
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