Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure
New England Journal of MedicinePublished 19 May 2004
Michael R. Bristow, Leslie A. Saxon, John Boehmer, Steven K. Krueger, David A. Kass, Teresa De Marco
Citations5,773
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In patients with advanced heart failure and a prolonged QRS interval, cardiac-resynchronization therapy decreases the combined risk of death from any cause or first hospitalization and, when combined with an implantable defibrillator, significantly reduces mortality.
Abstract
In patients with advanced heart failure and a prolonged QRS interval, cardiac-resynchronization therapy decreases the combined risk of death from any cause or first hospitalization and, when combined with an implantable defibrillator, significantly reduces mortality.
Keywords
Medicine
New England Journal of MedicineProphylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
6,873 Citations2002Arthur J. Moss, Wojciech Zaręba +8 more
In patients with a prior myocardial infarction and advanced left ventricular dysfunction, prophylactic implantation of a defibrillator improves survival and should be considered as a recommended therapy.
New England Journal of MedicineCardiac Resynchronization in Chronic Heart Failure
4,588 Citations2002William T. Abraham, Westby G. Fisher +15 more
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.
CARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
3,802 Citations2002W Illiam T. A Braham, W Estby G. F Isher +11 more
BiometricsA Multiple Testing Procedure for Clinical Trials
3,349 Citations1979Peter C. O’Brien, Thomas R. Fleming
The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
BiometrikaDiscrete sequential boundaries for clinical trials
1,740 Citations1983K. K. Gordon Lan, David L. DeMets
A more flexible way to construct discrete sequential boundaries is proposed, based on the choice of a function, a*(t), which characterizes the rate at which the error level ac is spent.
CirculationEffect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure
1,128 Citations2003Martin G. St. John Sutton, Ted Plappert +12 more
CRT in patients with moderate-to-severe heart failure who were treated with optimal medical therapy is associated with reverse LV remodeling, improved systolic and diastolic function, and decreased MR.
Journal of the American College of Cardiologylong-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay
1,026 Citations2002Angelo Auricchio, Christoph Stellbrink +10 more
Cardiac resynchronization therapy produces a long-term improvement in the clinical symptoms of patients with HF who have a ventricular conduction delay, and the differences between optimized biventricular and unIVentricular therapy appear to be small for short-term treatment.
Journal of the American College of CardiologyLong-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study
976 Citations2002Cecilia Linde, Christophe Leclercq +12 more
The clinical benefits of BiV pacing appeared to be significantly maintained over a 12-month follow-up period.
American Heart JournalLeft bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: A report from the Italian network on congestive heart failure
797 Citations2002Samuele Baldasseroni, Cristina Opasich +10 more
The data may support the rationale of randomized trials to verify the effects on mortality rate of ventricular resynchronization with multisite cardiac pacing in patients with CHF and LBBB.
CirculationLeft Ventricular or Biventricular Pacing Improves Cardiac Function at Diminished Energy Cost in Patients With Dilated Cardiomyopathy and Left Bundle-Branch Block
758 Citations2000Gregory S. Nelson, Ronald D. Berger +5 more
Ventricular resynchronization by left ventricular or biventricular pacing/stimulation in DCM patients with left bundle-branch block acutely enhances systolic function while modestly lowering energy cost should prove valuable for treating DCM Patients with basal dyssynchrony.
Journal of the American College of CardiologyCardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias
711 Citations2003Steven L. Higgins, John D. Hummel +9 more
The CRT improved functional status in patients indicated for an ICD who also have symptomatic HF and intraventricular conduction delay and a subgroup of patients with advanced HF consistently demonstrated improvement across all functional status end points.
Journal of the American College of CardiologyTissue doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy
604 Citations2002Peter Søgaard, Henrik Egeblad +5 more
Cardiac resynchronization significantly improved LV function and reversed LV remodeling during long-term follow-up and can be identified by TDI before implantation of a biventricular pacemaker.
International Journal of CardiologyIntraventricular conduction delay: a prognostic marker in chronic heart failure
407 Citations1999Waqar Shamim, Dárrel P. Francis +5 more
It is found that IVCD is an important ECG predictor of prognosis in patients with CHF, and that there is a graded increase in mortality with increasing value of IVCD.
Journal of Cardiac FailureHeart failure management using implantable devices for ventricular resynchronization: Comparison of medical therapy, pacing, and defibrillation in chronic heart failure (COMPANION) trial
328 Citations2000Michael R. Bristow, Arthur M. Feldman +1 more
The COMPANION study is a randomized, open-label, 3-arm study of patients in New York Heart Association class III or IV with an ejection fraction of 35% or less and a QRS duration of 120 milliseconds or less to determine whether optimal pharmacological therapy used with ventricular resynchronization therapy alone or with cardioverter-defibrillator capability is superior to optimal Pharmacological therapy alone in reducing combined all-cause mortality and hospitalizations.
CirculationEffects of Long-Term Biventricular Stimulation for Resynchronization on Echocardiographic Measures of Remodeling
289 Citations2002Leslie A. Saxon, Teresa De Marco +4 more
Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved.
CardiologyImpact of Acute Biventricular Pacing on Left Ventricular Performance and Volumes in Patients with Severe Heart Failure
101 Citations2001Peter Søgaard, Won Yong Kim +5 more
Biventricular pacing improves LV systolic performance and reduces LV volumes during short-term treatment and provides important pathophysiological information on the degree of LV resynchronization and may contribute to improved patient selection.
Journal of the American College of CardiologyQuantitation of basal dyssynchrony and acute resynchronization from left or biventricular pacing by novel echo-contrast variability imaging
94 Citations2002Miho Kawaguchi, Taizo Murabayashi +5 more
The new imaging and regional dyssynchrony analysis methods provide quantitative assessment of resynchronization analogous to that previously obtained only by tagged magnetic resonance imaging and could provide a useful noninvasive method for both identifying candidates and following long-term therapy.
Current Opinion in CardiologyCardiac resynchronization therapy for heart failure: biventricular pacing and beyond
83 Citations2002William T. Abraham
The evolution of pacing in heart failure is reviewed and the underlying mechanisms that are potentially responsible for the improvement seen in patients receiving cardiac resynchronization therapy are discussed.
Elsevier eBooksData and Safety Monitoring Boards
49 Citations2002Lawrence M. Friedman
There is no substitute for the discussions that consider these complex issues in data monitoring, so the DSMBs uses numerous statistical and non-statistical approaches.
The Thoracic and Cardiovascular SurgeonBiventricular Pacing in Patients with ICD: How Many Patients are Possible Candidates?
21 Citations2002Christiane Werling, U Weisse +7 more
This paper presents a probabilistic procedure for estimating the total number of particles in the response of the immune cells of the central nervous system during the first trimester of pregnancy.
Current Cardiology ReportsCardiac resynchronization therapy
14 Citations2002Silke Trautmann, Michael Kloss +1 more
A review of the results reported in randomized trials for biventricular pacing focuses on questions that have not yet been answered.