Rift Valley fever antibody in human sera collected after an outbreak in domestic animals in Kenya
Transactions of the Royal Society of Tropical Medicine and HygienePublished 1 March 1992
Thomas M. Logan, F. G. Davies, Kenneth J. Linthicum, Thomas G. Ksiazek
Citations19
SJR quartileQ2
SJR score0.64
SNIP0.77
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TL;DR
RVF virus is a member of the family Bunyaviridae, genus Phlebovirus, and principally involved domestic sheep and cattle populations, particularly those imported into the country.
Abstract
T.M. Logan, F.G. Davies, K.J. Linthicum, T.G. Ksiazek; Rift Valley fever antibody in human sera collected after an outbreak in domestic animals in Kenya, T
Keywords
MedicineEnvironmental Science
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IntervirologyBunyaviridae
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TheEpizootic range of Rift Valley fever in Kenya is defined from the results of virus isolations during epizootics, and from an extensive serological survey of cattle which were exposed during an epizootsic, which has been the only evidence for the persistence of the virus in Kenya since 1968.
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Specific amino acid coding changes which may be involved in virus neutralization and may contribute to the virulence characteristics of RVFV are identified.
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An enzyme-linked immunosorbent assay (ELISA) was developed for the rapid detection of antibodies to Rift Valley fever virus (RVFV) in ovine and bovine sera, and in sera from sheep and cattle inoculated against RVFV, the hemagglutination-inhibition test in combination with the ELISA provided a better indication of response to killed RVFVs.
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The isolation in Kenya of arboviruses from mosquitoes and patients is reported and attempts are made to define their role in human disease.
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