Hepatocellular Carcinoma in Italian Patients with Cirrhosis
New England Journal of MedicinePublished 5 September 1991Open access
Massimo Colombo, Roberto de Franchis, E. Del Ninno, Angelo Sangiovanni, Cristina De Fazio, Maurizio Tommasini
Citations821
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In the West, as in Asia, patients with cirrhosis of the liver are at substantial risk for hepatocellular carcinoma, with a yearly incidence rate of 3 percent, and the screening program did not appreciably increase the rate of detection of potentially curable tumors.
Abstract
In the West, as in Asia, patients with cirrhosis of the liver are at substantial risk for hepatocellular carcinoma, with a yearly incidence rate of 3 percent. Our screening program did not appreciably increase the rate of detection of potentially curable tumors.
Keywords
Medicine
British journal of surgeryTransection of the oesophagus for bleeding oesophageal varices
7,959 Citations1973R. N. H. Pugh, I M Murray-Lyon +3 more
Emergency ligation of bleeding oesophageal varices using the Milnes Walker technique was performed in 38 patients, and in patients with good preoperative liver function this rose to 71% and the simple scoring system for grading the severity of disturbance of liver function was found to be of value in predicting the outcome of surgery.
Journal of the American Statistical AssociationNonparametric Estimation from Incomplete Observations
7,727 Citations1958Edward L. Kaplan, Paul Meier
Journal of Chronic DiseasesMaximum utilization of the life table method in analyzing survival
2,912 Citations1958Sidney J. Cutler, Fred Ederer
Acceptance of survival as a criterion for measuring the effectiveness of cancer therapy is attested to by the very large number of papers published every year reporting on the survival experience of cancer patients.
New England Journal of MedicineDetection of Antibody to Hepatitis C Virus in Prospectively Followed Transfusion Recipients with Acute and Chronic Non-A, Non-B Hepatitis
1,684 Citations1989Harvey J. Alter, Robert H. Purcell +5 more
It is concluded that hepatitis C virus is the predominant agent of transfusion-associated non-A, non-B hepatitis and that screening of donors for anti-HCV could prevent the majority of cases of the disease.
HepatogastroenterologyHepatogastroenterology
1,260 Citations2011Ren Zu-hai, Yong Xu +1 more
ICG15 retention test is more effective to predict and avoid liver failure for patients with hepatolithiasis after hepatectomy than Child-Pugh scoring system and may also decrease the morbidity and mortality rate through strict selection, thus increasing operative safety.
HepatologyProspective study of early detection of hepatocellular carcinoma in patients with cirrhosis
401 Citations1990Hiroko Oka, Narito KURIOKA +5 more
periodic monitoring by use of ultrasonography in particular is recommended for early detection of hepatocellular carcinoma, especially patients with cirrhosis or with a history of blood transfusion who are negative for HBsAg.
GastroenterologyNatural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis
395 Citations1986Masaaki Ebara, Masao Ohto +8 more
Serum alpha-fetoprotein levels were generally low, rarely assisted in diagnosis, but tended to increase when the mass attained a diameter of greater than 3 cm; sudden acceleration in the rate of increase in alpha- Fetoprotein level often coincided with a change of ultrasonic pattern to the massive one.
PubMed[Epidemiology of hepatocellular carcinoma].
328 Citations1992Ricca Rosellini S, F Miglio
In addition to HBV infection, cirrhosis, aflatoxins, alcohol, tobacco smoking and oral contraceptives have been evaluated as risk factors for HCC; the importance of the contribution of these risk factors to the development of HCC and the perspectives for prevention in different geographical areas will be discussed.
PubMed[Pathology of hepatocellular carcinoma].
314 Citations1983Masamichi Kojiro, M Kojiro
The pathology of HCC is described based on both autopsy and surgical materials with special reference to angioarchitecture, unusual tumor growth, and histological growth pattern of H CC.
GastroenterologyEarly detection of hepatocellular carcinoma in patients with chronic type B hepatitis
310 Citations1986Yun‐Fan Liaw, Dar‐In Tai +5 more
A combination of alpha-fetoprotein and ultrasonography surveillance in patients with chronic hepatitis is recommended in order to improve the chance of early HCC detection as well as the chance for successful resection.
Seminars in Liver DiseaseRelationship Between Hepatocellular Carcinoma and Cirrhosis
261 Citations1984Michael C. Kew, Hans Pópper
There is at present little evidence for the postulate that HCC is an inevitable consequence of the hyperplasia of cirrhosis, but an etiology common to the two disorders, HBV and possibly other hepatitis viruses, seems to account for the majority of cases.
The LancetRISK FACTORS IN DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN CIRRHOSIS: PROSPECTIVE STUDY OF 613 PATIENTS
260 Citations1985Shafquat Zaman
Seropositivity for hepatitis B surface antigen may be associated with hepatocellular carcinoma only because hepatitis B virus infection is a common cause of cirrhosis.
CancerEarly detection of hepatocellular carcinoma by real-time ultrasonography. A prospective study
214 Citations1985Jin‐Chuan Sheu, Juei‐Low Sung +10 more
It is concluded that real‐time US is more sensitive than AFP assay in early detection of HCC, and the high‐risk subjects should receive this procedure at regular intervals.
Journal of HepatologyCirrhosis and the aetiology of hepatocellular carcinoma
174 Citations1987Philip J. Johnson, Roger Williams
There are a certain number of cases of cancer of the liver which seem to show that this disease, in the absence of any primary source elsewhere, may be secondary to cirrhosis.
Vitae (Universidad de Antioquia)Epidemiology of hepatocellular carcinoma
156 Citations2007Raymundo Paraná, Delvone Almeida
TechnometricsTheory and Applications of Hazard Plotting for Censored Failure Data
136 Citations1972Wayne Nelson
CancerEvaluation of the prognosis for small hepatocellular carcinoma based on tumor volume doubling time. A preliminary report
119 Citations1989Nobuo Okazaki, Masahiro Yoshino +9 more
It is indicated that tumor volume doubling time is one of the determining factors of survival length in patients with hepatocellular carcinoma, and, therefore, can be used in the evaluation of therapeutic efficacy.
HepatologyScreening Methods for Early Detection of Hepatocellular Carcinoma
119 Citations1985Kenichi Kobayashi, Tatsuho Sugimoto +6 more
Although it was difficult to differentiate hepatocellular carcinoma from other lesions in the case of “space‐occupying lesions” smaller than 2 cm in diameter, the results suggest that regularly scheduled screening may be useful to detect early hepato Cell carcinoma.
GastroenterologyDetection of hepatocellular carcinoma during a clinical follow-up of chronic liver disease
111 Citations1978Yasuhiko Kubo, Kunio Okuda +2 more
Although continuous and regular check for alpha-fetoprotein is imperative in patients with chronic liver disease, particularly in those with hepatitis B surface antigenemia, additional diagnostic tools are necessary for the detection of small HCC in its resectable stage.
CancerTumor invasiveness and prognosis in resected hepatocellular carcinoma.Clinical and pathogenetic implications
108 Citations1988Hey‐Chi Hsu, Tsung‐Teh Wu +4 more
It was concluded that invasiveness of an H CC is the most crucial factor in determining the long‐term outcome for the patient, and that the clinical course of resected HCC is predictable in a great majority of the cases.
HepatologyHistological features and clinical course of large regenerative nodules: Evaluation of their precancerous potentiality
97 Citations1990Fukuo Kondo, Masaaki Ebara +8 more
Seventeen patients with cirrhosis and histologically defined, ultrasonically detected, large regenerative nodules of the liver were followed without treatment for more than 1 yr, and none of the nodules were demonstrated sonographically to have enlarged.
Digestive Diseases and SciencesUltrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis
71 Citations1988Alberto Maringhini, Mario Cottone +6 more
The accuracy of ultrasound (US) and alpha-fetoprotein (AFP) in the diagnosis of hepatocellular carcinoma (HCC) in 363 patients with cirrhosis (C) and a clinical suspicion of HCC was assessed and an algorithm for diagnosis is proposed.
Liver InternationalFollow‐up study of 582 liver cirrhosis patients for 26 years in Japan
45 Citations1987Ryoji Tanaka, Tatsuya Itoshima +1 more
A long-term follow-up study of liver cirrhosis in Japan, where patients diagnosed by peritoneoscopy and liver biopsy survived 40-44% of the life expectancy of the general population in Japan in all age groups, Cox's multiregression life-table method selected three important prognostic factors from 7 parameters: a poor prognosis with a history of heavy alcohol consumption and old age at onset, and a better prediction with recent onset.
Seminars in Surgical OncologyThe changing role of surgery in the treatment of primary liver cancer
21 Citations1986Zhao–You Tang, Ye‐Qin Yu +1 more
The results indicated that early resection, reoperation for subclinical recurrence, resection of huge PLC in stages, and combination of palliative surgery other than resection might be responsible for the increasing 5-year survival rate.
Liver InternationalHepatocellular carcinoma in Italy: report of a clinical trial with intravenous doxorubicin
21 Citations1985Massimo Colombo, Maurizio Tommasini +4 more
Initial performance status and the degree of hepatic impairment were found to be covariates of prognostic significance and the type and severity of drug-related side-effects appeared to be comparable to those reported by others.
