THE PSYCHOSEDATIVE PROPERTIES OF METHAMINODIAZEPOXIDE

This compound showed anticonvulsant activity in mice and anti-inflammatory effects in Rats and dogs and Chronic administration to rats and dogs did not produce severe toxic manifestations; no evidence of cumulative toxicity or deleterious effects on the processes of reproduction were detected.

Abstract

Methaminodiazepoxide shows muscle relaxant and sedative effects in mice. It depresses avoidance responding and spontaneous locomotor activity of normal rats and has a calming effect on rats made irritable by lesions in the septal area of the brain. In dogs, it produced ataxia at doses below those causing sleep. In monkeys, a loss of agressive behavior was observed at doses which did not depress general activity or avoidance behavior. This compound showed anticonvulsant activity in mice and anti-inflammatory effects in rats. It produced appetite stimulation in rats and dogs. Chronic administration to rats and dogs did not produce severe toxic manifestations; no evidence of cumulative toxicity or deleterious effects on the processes of reproduction were detected.