2,3,7,8-Tetrachlorodibenzo-p-dioxin: Failure to demonstrate toxicity in twenty-three cultured cell types
Toxicology and Applied PharmacologyPublished 1 July 1980
Joyce C. Knutson, Alan Poland
Citations87
SJR quartileQ2
SJR score0.91
SNIP0.79
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TL;DR
Examination of the cells for altered morphology, decrease in percentage viability, or diminished growth rate revealed no toxic effect of TCDD in any cell type, including those which respond to T CDD with the induction of aryl hydrocarbon hydroxylase activity.
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), one of the most potent small molecule toxins known was investigated for its toxic effect on 23 cultured cell types, including primary cultures and cells from established and transformed cell lines. The cells, derived from tissues and/or species susceptible to TCDD toxicity in vivo, were exposed to TCDD for an extended period, usually a week or longer. Examination of the cells for altered morphology, decrease in percentage viability, or diminished growth rate revealed no toxic effect of TCDD in any cell type, including those which respond to TCDD with the induction of aryl hydrocarbon hydroxylase activity.
Keywords
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