The effect of morphine on pituitary-thyroid function in the rat
European Journal of PharmacologyPublished 1 March 1974
John L. Bakke, Nancy Lawrence, Sue Robinson
Citations20
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
It is suggested that these endocrine changes may be mediated by Mo acting at a hypothalamic level to enhance TSH synthesis under certain experimental conditions.
Abstract
The administration of morphine (Mo) to adult male rats resulted in a decrease in body weight, thyroid weight and pituitary-thyroid-stimulating hormone (TSH) content and in increase in pituitary and adrenal weight. Serum TSH and goiter growth on propylthiouracil (PTU) challenge was normal. Stalk-median eminence (SME) TSH content was increased and net TSH synthesis as measured over 24 hr was augmented in Mo-treated rats. It is suggested that these endocrine changes may be mediated by Mo acting at a hypothalamic level to enhance TSH synthesis under certain experimental conditions.
Keywords
MedicineNeuroscience
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