Immunity to West Nile virus
Current Opinion in ImmunologyPublished 17 June 2004
Tian Wang, Erol Fikrig
Citations48
SJR quartileQ1
SJR score2.74
SNIP1.38
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TL;DR
Understanding of West Nile virus pathogenesis and immunity is increased, which will facilitate the development of effective vaccines and therapies to combat WN virus.
Abstract
Over the past five years, West Nile (WN) virus has emerged as an important public health concern in the United States. Recent studies from experimental models of WN virus infection have increased our understanding of its pathogenesis and immunity. These include the demonstration that the gene encoding 2'-5'oligoadenylate synthetase is responsible for murine susceptibility to WN virus, the elucidation of the contributions of B, CD8(+) and gamma T cells in the control of murine WN virus infection, and the use of active immunization with envelope protein and passive transfer of immunoglobulin for immunotherapy. These efforts will facilitate the development of effective vaccines and therapies to combat WN virus.
Keywords
Medicine
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