Marijuana smoking as cause of reduction in single-breath carbon monoxide diffusing capacity
The American Journal of MedicinePublished 1 April 1986
Dan S. Tilles, Paul D. Goldenheim, Douglas C. Johnson, Jack H. Mendelson, Nancy K. Mello, Charles A. Hales
Citations39
SJR quartileQ1
SJR score1.00
SNIP1.04
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TL;DR
The results suggest that heavy marijuana smoking when added to tobacco smoking may damage the gas exchange surface of the lung.
Abstract
To investigate the effects of chronic marijuana smoking on lung function, pulmonary function tests including single-breath carbon monoxide diffusing capacities were performed in 15 healthy women who smoked 1.7 +/- 1.4 (mean +/- SD) marijuana cigarettes per day for 235 +/- 135 days per year for a mean of 10.5 +/- 3.7 years. Control groups included 27 nonsmoking and 26 tobacco-smoking women. Results revealed that marijuana smoking with or without tobacco is associated with a reduction in the single-breath carbon monoxide diffusing capacity to 74 +/- 20 percent of predicted, which was significantly different from that in the nonsmoking control subjects (92 +/- 11 percent; p less than 0.05). The subset of subjects who smoked marijuana and tobacco had a further reduction of the single-breath carbon monoxide diffusing capacity to 65 +/- 17 percent, which was significantly different from that in both nonsmoking and smoking control subjects (80 +/- 7 percent). These results suggest that heavy marijuana smoking when added to tobacco smoking may damage the gas exchange surface of the lung.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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