Role of the AMP-activated protein kinase in the cellular stress response
Current BiologyPublished 1 April 1994
Julia M. Corton, John G. Gillespie, D. Grahame Hardie
Citations429
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
The results suggest that a major function of the AMP-activated protein kinase is to act protectively, switching off biosynthetic pathways when the cell is subjected to stress that causes ATP depletion, the key signal being a rise in AMP level.
Abstract
Our results suggest that a major function of the AMP-activated protein kinase is to act protectively, switching off biosynthetic pathways when the cell is subjected to stress that causes ATP depletion, the key signal being a rise in AMP level. By this mechanism, ATP is preserved for processes that may be more essential in the short term, such as the maintenance of ion gradients. This function of the kinase represents a novel role for protein phosphorylation.
Keywords
Biochemistry, Genetics and Molecular Biology
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