In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep–wakefulness
Brain ResearchPublished 1 July 1999
Sung Pa Park, Fernando López Rodríguez, Charles L. Wilson, Nigel T. Maidment, Yosuke Matsumoto, Jerome Engel
Citations68
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Extracellular 5-hydroxytryptamine levels in rat hippocampus during different stages of the sleep-waking cycle are investigated using in vivo microdialysis and functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
Abstract
We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
Keywords
Neuroscience
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