THE CLINICAL SIGNIFICANCE OF INDOMETHACIN‐PROBENECID INTERACTION
British Journal of Clinical PharmacologyPublished 1 August 1974Open access
Peter Brooks, M. Anne Bell, R D Sturrock, J. P. Famaey, W C Dick
Citations49
SJR quartileQ1
SJR score1.16
SNIP1.20
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TL;DR
Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
Abstract
1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
Keywords
Medicine
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