Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
CancerPublished 15 September 2001
Steven A. Ahrendt, P. Decker, Enas Alawi, Yong-ran Zhu, Montse Sánchez‐Céspedes, Stephen C. Yang
Citations444
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
K‐ras gene mutations are common in lung adenocarcinoma and have been associated with cigarette smoking, asbestos exposure, and female gender.
Abstract
The results of the current study confirm and extend previous observations that smokers with adenocarcinoma of the lung are more likely to have K-ras mutant tumors compared with nonsmokers. The strong link between cigarette smoking and K-ras mutations in adenocarcinoma of the lung supports the role of specific tobacco carcinogens in the etiology of this malignancy.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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