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VEGF gene therapy: stimulating angiogenesis or angioma-genesis?

Nature MedicinePublished 1 October 2000
Peter Carmeliet
Citations366
SJR quartileQ1
SJR score18.33
SNIP8.71

TL;DR

The finding that unregulated, continuous delivery of vascular endothelial growth factor to the myocardium causes the formation of hemangiomas and death in mice indicates that more research is required on this potent molecule before clinical trials can proceed.

Abstract

The finding that unregulated, continuous delivery of vascular endothelial growth factor to the myocardium causes the formation of hemangiomas and death in mice indicates that more research is required on this potent molecule before clinical trials can proceed.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology