The P-loop — a common motif in ATP- and GTP-binding proteins
Trends in Biochemical SciencesPublished 1 November 1990
Matti Saraste, Peter R. Sibbald, Alfred Wittinghofer
Citations2,070
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
Current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.
Abstract
Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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