Chromosomal location of the gene determining uridine diphoglucose formation in Escherichia coli K-12.
Journal of BacteriologyPublished 1 January 1966Open access
James A. Shapiro
Citations30
SJR quartileQ2
SJR score1.09
SNIP0.85
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TL;DR
Strains of Escherichia coli K-12 which cannot synthesize uridine diphosphoglucose (UDPG) have a complex phenotype and are sensitive to phage C21 because of their inability to incorporate galactose into the cell wall.
Keywords
Biochemistry, Genetics and Molecular Biology
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A map of the gal-try region of the Escherichia coli chromosome is presented, including the location of two amber and two ochre suppressor mutations, and the three suppressors tested are dominant with respect to the corresponding suppressor negative alleles.
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Growth of the phages T2 and T4 in E. coli mutant strains defective in the enzyme UDPG-pyrophosphorylase yields phage particles of the T* type, whose DNA contains only about 10 per cent as much glucose as that of normal phage.
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The hypothesis that a genetic block in the pathway of synthesis of UDPG, especially the enzyme UDPG synthetase, is defective has been fully substantiated as will appear from the present study.
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The ability of the bacteria to utilize galactose depends on the production of catalytic amounts of UDPG and on the interconversion of glucose-l-phosphate and glucose-6-ph phosphate by reactions catalyzed by UDPG pyrophosphorylase and phosphoglucomutase, re-spectively.