The Pathophysiology of Schizophrenia Disorders: Perspectives From the Spectrum
American Journal of PsychiatryPublished 1 March 2004
Larry J. Siever, Kenneth L. Davis
Citations509
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TL;DR
Genetic or environmental factors that promote greater frontal capacity and reduced striatal dopaminergic reactivity might contribute to sparing people with schizotypal personality disorder from the psychosis and severe social and cognitive deterioration of chronic schizophrenia.
Abstract
Genetic or environmental factors that promote greater frontal capacity and reduced striatal dopaminergic reactivity might contribute to sparing people with schizotypal personality disorder from the psychosis and severe social and cognitive deterioration of chronic schizophrenia. Further research is required to test these hypotheses more definitively.
Keywords
PsychologyMedicineArts and Humanities
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75 Citations1998Igor Elman, Caleb M. Adler +4 more
Patients with schizophrenia have an exaggerated ACTH response to acute metabolic stress exposure, and ACTH elevations were significantly greater in patients with schizophrenia than in comparison subjects.
Schizophrenia ResearchVisuospatial working memory in schizotypal personality disorder patients
74 Citations2000Sonia E. Lees Roitman, Vivian Mitropoulou +7 more
Like schizophrenic patients, SPD patients demonstrate working memory impairment compared to normal controls, and this impairment may be specific to the schizophrenia-related personality disorders.
Schizophrenia ResearchTemporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia
69 Citations2001J.E. Downhill, Monte S. Buchsbaum +10 more
The results suggest that the psychopathological symptoms of SPD may be related to temporal gray matter loss with relatively intact white matter connectivity, while the cognitive and psychotic symptoms of schizophrenia may be associated with temporal gray loss combined with disruption of normal patterns of white matter development.
American Journal of Medical GeneticsDRD4 exon 3 variants associated with delusional symptomatology in major psychoses: A study on 2,011 affected subjects
65 Citations2001Alessandro Serretti, Roberta Lilli +3 more
This analysis in an enlarged sample suggests that DRD4*Long alleles exert a small but significant influence on the delusional symptomatology in subjects affected by major psychoses.
American Journal of PsychiatrySmaller Left Heschl’s Gyrus Volume in Patients With Schizotypal Personality Disorder
64 Citations2002Chandlee C. Dickey, Robert W. McCarley +7 more
Smaller left Heschl's gyrus gray matter volume in subjects with schizotypal personality disorder may help to explain the previously reported abnormality in the left superior temporal gyrus and may be a vulnerability marker for schizophrenia spectrum disorders.
Schizophrenia ResearchRegional cerebral blood flow during the wisconsin card sort test in schizotypal personality disorder
63 Citations1997Monte S. Buchsbaum, Robert L. Trestman +11 more
At least some SPD patients demonstrate abnormal patterns of prefrontal activation, perhaps as a compensation for dysfunction in other regions, as measured by regional cerebral blood flow.
American Journal of PsychiatryEye movement impairment and schizotypal psychopathology
59 Citations1994L.J. Siever, Lee Friedman +8 more
Patients with schizotypal personality disorder demonstrate qualitatively poorer tracking than comparison groups, and the impaired tracking is associated with deficit-like symptoms.
Harvard Review of PsychiatrySchizophrenia: A Review of Genetic Studies
58 Citations1999Ming T. Tsuang, William S. Stone +1 more
NeuropsychopharmacologyEffects of Amphetamine on Visuospatial Working Memory Performance in Schizophrenia Spectrum Personality Disorder
57 Citations2000Richelle Kirrane
Oral amphetamine was administered to patients with schizophrenia spectrum personality disorders and other, nonschizophrenia-related personality disorders to determine if amphetamine improves visuospatial working memory, which is impaired in the schizophrenia spectrum and may be modulated by dopamine in prefrontal cortex.
Biological PsychologyLatent inhibition as a function of schizotypality and gender: implications for schizophrenia
57 Citations2002R. E. Lubow, L.G. De la Casa
Findings with schizophrenic patients suggest a sexual dimorphism of cognitive dysfunction in schizophrenia, particularly in regard to the processing of irrelevant stimuli.
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