The Effect of Systemic Lidocaine on Pain and Secondary Hyperalgesia Associated with the Heat/Capsaicin Sensitization Model in Healthy Volunteers
Anesthesia & AnalgesiaPublished 1 October 2000
Jesper Dirks, P. G. Fabricius, Karin L. Petersen, Michael C. Rowbotham, Jørgen B. Dahl
Citations100
SJR quartileQ1
SJR score1.16
SNIP1.63
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TL;DR
It is concluded that, at infusion rates in the low- to mid-antiarrhythmic range, lidocaine has no effect on acute nociceptive pain but does have a limited and selective effect on secondary hyperalgesia.
Abstract
The efficacy of systemic lidocaine in nonneuropathic pain remains uncertain. This study investigates the effect of systemic lidocaine on experimental-induced hyperalgesia in 25 volunteers. Hyperalgesia was induced by using an experimental pain model that uses heat and capsaicin in combination. Systemic lidocaine showed a selective effect on secondary hyperalgesia.
Keywords
Medicine
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