Inner city care.
BMJPublished 2 May 1987Open access
Robert Hull
Citations2
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MedicineBusiness, Management and Accounting
Journal of Clinical InvestigationAcetaldehyde adducts with hemoglobin.
329 Citations1981Victor J. Stevens, Wendy J. Fantl +4 more
The amount of these adducts was found to be significantly elevated in hemoglobin from alcoholics as compared with normal volunteers, and the acetaldehyde-modified amino acid residues appear to exist in interconvertible conformations, only one of which is reducible by sodium borohydride.
The Journal of Cell BiologyCYTOMORPHOMETRY OF DEVELOPING RAT LIVER AND ITS APPLICATION TO ENZYMIC DIFFERENTIATION
318 Citations1972Olga Greengard, Micheline Federman +1 more
In late fetal liver, only rises in enzyme concentration less than twofold may be attributed to the enrichment of parenchymal tissue at the expense of hematopoietic elements, and these are the main ones for interpreting the biochemical differentiation of liver.
Archives of Biochemistry and BiophysicsAcetaldehyde adducts with proteins: Binding of [14C]acetaldehyde to serum albumin
208 Citations1983Terrence M. Donohue, Dean J. Tuma +1 more
Results indicate that acetaldehyde can covalently bind to protein and form unstable as well as stable adducts.
Archives of Biochemistry and BiophysicsThe effect of acetaldehyde on mitochondrial function
145 Citations1974Arthur I. Cederbaum, Charles S. Lieber +1 more
The data suggest that acetaldehyde may be implicated in some of the toxic effects caused by chronic ethanol consumption, as the malate-aspartate, α-glycerophosphate, and fatty acid shuttles for the transfer of reducing equivalents, and oxidation by mitochondria, were highly sensitive to acetaldehyde.
Journal of Molecular and Cellular CardiologyAlcoholic cardiomyopathy II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde
90 Citations1974Shaul Schreiber
At concentrations seen in humans following ethanol ingestion, acetaldehyde interferes with normal cardiac protein synthesis independent of contractile action and thus may play a role in the ultimate development of ethanolic cardiomyopathy.
Clinical ScienceLipid Peroxidation in Iron-Overloaded Spleens
81 Citations1981A. D. Heys, T. L. Dormandy
Iron-overloaded spleens from thalassaemic subjects showed a greatly increased susceptibility to free-radical oxidation (peroxidation) in vitro, and added ascorbate had a dose-dependent action either as an antioxidant or as a pro-oxidant, the direction of its effect depending mainly on the degree of iron overload.
PubMedCovalent binding of acetaldehyde to hepatic proteins during ethanol oxidation.
76 Citations1985Victor A. Medina, Terrence M. Donohue +2 more
It was demonstrated that acetaldehyde formed both stable and unstableAdducts with hepatic proteins and that unstable adducts may undergo conversion to form stable adductions during incubation.
The LancetCYTOTOXIC PROTEIN MOLECULES GENERATED AS A CONSEQUENCE OF ETHANOL METABOLISM IN VITRO AND IN VIVO
64 Citations1986S. N. Wickramasinghe, Brigitte Gardner +1 more
The appearance of a circulating long-acting cytotoxic macromolecule after the ingestion of ethanol may be of considerable importance in clarifying the mechanisms underlying ethanol-induced tissue damage.
Biochemical PharmacologyInhibition of glycoprotein secretion by ethanol and acetaldehyde in rat liver slices
48 Citations1980Dean J. Tuma, Rowen K. Zetterman +1 more
The results indicate that ethanol via its metabolite, acetaldehyde, impairs the secretion of glycoproteins by the liver and suggest that this impairment follows the attachment of the terminal monosaccharides in the Golgi membrane.
PubMedThe effects of ethanol and acetaldehyde on the products of protein synthesis by liver mitochondria.
46 Citations1979Burke Jp, Emanuel Rubin
The data suggest that chronic ethanol consumption interferes with mitochondrial membrane biogenesis and that several products are more sensitive to this effect than others.
Alcohol and AlcoholismTHE EFFECTS OF CHRONIC ALCOHOL CONSUMPTION ON PREGNANT RATS AND THEIR OFFSPRING
39 Citations1986R. Sanchís, María Sancho‐Tello +1 more
It is shown that chronic ethanol intake during pregnancy lengthens the gestation period, decreases foetal viability, increases the placental weight and diminishes foetus, liver and brain weights, as well as the protein and DNA content offoetal brain.
Alcohol and AlcoholismOBSERVATIONS ON THE BIOCHEMICAL BASIS OF ETHANOL METABOLISM BY HUMAN MACROPHAGES
30 Citations1986S. N. Wickramasinghe
The data suggest that most of the ethanol metabolism by blood-monocyte-derived macrophages is mediated via the cytochrome-P-450-dependent microsomal ethanol-oxidising system.
Alcoholism Clinical and Experimental ResearchNeuroglial and Neuroblastoma Cell Lines Are Capable of Metabolizing Ethanol Via an Alcohol‐Dehydrogenase‐Independent Pathway
29 Citations1987S. N. Wickramasinghe
The data emphasize the possibility that the neurotoxicity of ethanol may be related to a relatively high ethanol-metabolizing capability of neural tissue and particularly of neuroglial cells.
Acta HaematologicaInvestigations into the Production of Acetate from Ethanol by Human Blood and Bone Marrow Cells in vitro
27 Citations2009A.N. Bond, S. N. Wickramasinghe
It is concluded that bone marrow cells have a considerable capacity to metabolize ethanol and that the predominant biochemical pathway involved in this metabolism is different from that involved in rat hepatocytes.
Alcoholism Clinical and Experimental ResearchAcetaldehyde Causes a Prolongation of the Doubling Time and an Increase in the Modal Volume of Cells in Culture
24 Citations1986S. N. Wickramasinghe, Fayaz Malik
The results indicate that relatively low concentrations of acetaldehyde cause an impairment of cell proliferation and an abnormality of cell growth in vitro and support the possibility that ethanol-derived acetaldehyde may be responsible for some aspects of tissue damage in chronic alcoholics.
Alcohol and AlcoholismRATES OF METABOLISM OF ETHANOL TO ACETATE BY HUMAN NEUTROPHIL PRECURSORS AND MACROPHAGES
21 Citations1985S.N. Wickramasinghe
The data indicate that neutrophils and their granule-containing precursors contribute relatively little and macrophages contribute substantially to the overall rate of ethanol metabolism by suspensions of nucleated marrow cells.
Alcohol and AlcoholismThe role of acetaldehyde in drinking behaviour and tissue damage
21 Citations1982C. J. Peter Eriksson
Elevated acetaldehyde levels inhibit ethanol drinking in both experimental animals and humans, and it remains to be proved if there is a connection between the acetaldehyde-mediated acute inhibition of protein synthesis and the pathogenesis of alcoholic-tissue damage.
British Journal of AddictionAcetaldehyde: Its Role in Alcoholic Toxicity and Dependence
17 Citations1981Merlin C. Thomas, T. J. Peters