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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

New England Journal of MedicinePublished 2 September 1999Open access
Bertram Pitt, Faı̈ez Zannad, Willem J. Remme, Robert Cody, A Castaigne, A.J. Pérez Pérez
Citations8,985
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR

Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.

Abstract

Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.

Keywords

Medicine