Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation
Journal of Pediatric SurgeryPublished 1 March 2005
Anthony Stallion, Tzuyung D. Kou, Samir Latifi, Kelly A. Miller, Beverly Barrett Dahms, David Dudgeon
Citations101
SJR quartileQ1
SJR score0.95
SNIP1.40
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TL;DR
This reproducible model of systemic inflammation elicits variable responses from genetically different animals, the results of which may lead to a better understanding of MSOF.
Abstract
This model mimics what is observed clinically with intestinal injury resulting from a progressive ischemic insult with eventual systemic manifestations. This reproducible model of systemic inflammation elicits variable responses from genetically different animals, the results of which may lead to a better understanding of MSOF.
Keywords
Immunology and MicrobiologyMedicine
Cellular and Molecular Immunology
3,363 Citations1994Abul K. Abbas, Andrew H. Lichtman +1 more
Postgraduate Medical JournalCellular and Molecular Immunology
2,816 Citations1992A. M. Denman
This sales letter may not influence you to be smarter, but the book that the authors offer will evoke you to being smarter and you'll know more than others who don't.
Annals of SurgeryMultiple Organ Failure Pathophysiology and Potential Future Therapy
1,389 Citations1992Edwin A. Deitch
The goals of this review are to integrate the vast amount of new information on the basic biology of MOF and to focus special attention on the potential therapeutic consequences of these recent advances in the authors' understanding of this complex and perplexing syndrome.
CHEST JournalSerum Cytokine Levels in Human Septic Shock
884 Citations1993Michael R. Pinsky, Jean‐Louis Vincent +4 more
TNF and IL-6 serum levels are higher in septic than in nonseptic shock, but the persistence of TNF andIL-6 in the serum rather than peak levels of cytokines predicts a poor outcome in patients with shock.
CHEST JournalPersistent Elevation of Inflammatory Cytokines Predicts a Poor Outcome in ARDS
807 Citations1995G. Umberto Meduri, Stacey Headley +5 more
The findings indicate that unfavorable outcome in acute lung injury is related to the degree of inflammatory response at the onset and during the course of ARDS.
Critical Care MedicineEarly enteral administration of a formula (Impact Registered Trademark) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients
589 Citations1995Robert H. Bower, Frank B. Cerra +8 more
Early enteral feeding of the experimental formula was safe and well tolerated in ICU patients and a substantial reduction in hospital length of stay was observed, along with a significant reduction in the frequency of acquired infections.
PubMedThe sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion.
435 Citations1990P O Park, U Haglund +2 more
Overall, total intestinal ischemia may be followed by reperfusion injury if there is no concomitant congestion and if ischemic injury is not too extensive, and total arterial occlusion was employed without conComitant venous congestion.
Nature ImmunologyIL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice
287 Citations2001Tilo Biedermann, Stephan Zimmermann +12 more
It is shown that when present during the initial activation of dendritic cells by infectious agents, IL-4 instructed DCs to produce IL-12 and promote TH1 development, which established resistance to Leishmania major in susceptible BALB/c mice.
ShockEVIDENCE FAVORING THE ROLE OF THE GUT AS A CYTOKINE-GENERATING ORGAN IN RATS SUBJECTED TO HEMORRHAGIC SHOCK
286 Citations1994Edwin A. Deitch, Da-Zhong Xu +3 more
After hemorrhagic shock, the gut appears to become a cytokine liberating organ even in the absence of detectable bacteria in the portal circulation as measured by measuring interleukin 6 and tumor necrosis factor levels.
Intensive Care MedicineTime course of cytokine levels in sepsis
201 Citations1995L. G. Thijs, C. Erik Hack
Elevated blood levels of anti-inflammatory cytokines (IL-10), as well as of soluble cytokine receptors (sTNF-RI and II, IL-lra), have been found, and seem to have a regulatory function in the host response.
PubMedSplanchnic ischemia and gut mucosal injury in sepsis and the multiple organ dysfunction syndrome.
198 Citations1996Stephen M. Pastores, David P. Katz +1 more
Current concepts of the pathogenesis and pathophysiology of MOFS are discussed, with particular emphasis on the roles of splanchnic ischemia and gut barrier failure in the development of both sepsis and the maintenance of the systemic inflammatory response that leads to MOFS.
British journal of surgeryInterleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis
177 Citations1994R T Patel, K.I. Deen +3 more
International Journal of Molecular MedicineOrgan dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review).
170 Citations1999Doraid Jarrar, Irshad H. Chaudry +1 more
This review focuses on factors and mediators responsible for producing cell and organ dysfunctions, especially hepatocellular dysfunction, following trauma, hemorrhagic shock, and sepsis, and the role of mitogen-activated protein kinases, transcription factors, nitric oxide, heat shock proteins, and inflammatory cytokines.
Critical Care ClinicsPATHOGENESIS AND MANAGEMENT OF MULTIPLE ORGAN DYSFUNCTION OR FAILURE IN SEVERE SEPSIS AND SEPTIC SHOCK
157 Citations2000R.A. Balk
The presence of organ dysfunction has great clinical impact on the underlying disease process, can prolong the hospital stay, increase the cost of care, and has been associated with an increase in mortality rate.
SurgeryInterleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion
132 Citations1997John S. Lane, Karen E. Todd +6 more
IL-10 reduced the severity of local and systemic inflammation in a murine model of intestinal I/R when given before or after reperfusion injury, suggesting that IL-10 may exert its effect by blocking cytokine production and distant organ neutrophil accumulation.
Langenbeck s Archives of SurgeryIntestinal ischemia - the basics
123 Citations1999U Haglund, David Bergqvist
The physiology of the intestinal circulation of importance for the understanding of intestinal ischemia is briefly outlined and the special situation with sigmoid gangrene following surgery for ruptured aortic aneurysm is discussed.
PubMedTrauma, shock, and gut translocation.
108 Citations1996Edwin A. Deitch, Randi L. Rutan +1 more
The scientific and clinical evidence that supports trauma and shock as potential etiologies for translocation of intestinal microorganisms and their by-products and the potential for loss of intestinal barrier function is reviewed.
Pediatric PathologyNecrotizing Enterocolitis: A Review of Pathogenetic Mechanisms and Implications for Prevention
97 Citations1993Michael S. Caplan, William MacKendrick
PubMedComparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock.
86 Citations1995M R Grotz, Jiayi Ding +3 more
The results suggest that different models of intestinal ischemia have different cytokine profiles and that the early TNF response associated with SMA occlusion model is primarily due to the laparotomy.
ShockGENETIC COMPONENT IN THE INFLAMMATORY RESPONSE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE
85 Citations1998Antonio De Maio, Maria de Lourdes Mooney +3 more
A genetic contribution was demonstrated for the inflammatory response induced by the administration of bacterial lipopolysaccharide in different, genetically distinct strains of inbred mice, illustrating that the response to injury could be modulated by the genetic background of the individual.
Surgical Clinics of North AmericaPREVENTION OF MULTIPLE ORGAN FAILURE
79 Citations1999Edwin A. Deitch, Elliot R. Goodman
Treatment of patients with established multiple organ failure is still largely supportive and has made little impact on the patient mortality rate over the past 20 years, so future treatment strategies must focus on multimodality combination therapy aimed at specifically suppressing excessive activation of the inflammatory response while preserving immune competence and normal antimicrobial defenses.
PubMedPost injury hypermetabolic response and magnitude of translocation: prevention by early enteral nutrition.
77 Citations1994Luca Gianotti, Jeffrey L. Nelson +3 more
It is concluded that bacterial translocation is reduced by early feeding and is an important cause of hypermetabolism and stress hormone production after burn injury.
ShockGENETIC CONTRIBUTION TO THE SEPTIC RESPONSE IN A MOUSE MODEL
73 Citations2002Dylan Stewart, William B. Fulton +5 more
A genetic contribution in the response to sepsis was evaluated in a mouse model induced in two inbred mouse strains, C57BL/6J (B6) and A/J, by cecal ligation and single puncture (CLP).
World Journal of SurgeryMortality following Lower Limb Ischemia‐Reperfusion: A Systemic Inflammatory Response?
70 Citations1996Magdi M.I. Yassin, A A B Barros D'Sa +4 more
Results indicate that reperfusion of the acutely ischemic lower limb is accompanied by structural changes in the gut mucosa associated with increased systemic endotoxin concentrations and cytokine activation and related to a systemic inflammatory response triggered by endotoxin of gut origin.
PubMedEffects of hemorrhage on cytokine gene transcription.
69 Citations1993Robert Shenkar, Edward Abraham
It is demonstrated that blood loss, even if resuscitated, produces significant increases in proinflammatory and immunoregulatory cytokine gene transcription as early as 1 hr following hemorrhage, suggesting a mechanism for the increased incidence of pulmonary and intestinal involvement in organ system failure following severe blood loss and injury.
The Journal of Trauma: Injury, Infection, and Critical CareThe Route of Feeding Influences Injury Responses
64 Citations1990STFPHEN F. JOWRY
Data are presented from both clinical and experimental studies to suggest that a lack of intestinal nutrient provision, such as that induced by parenteral feeding, appears to predispose to enhanced cytokine mediator production in hepatic tissues.
PubMedPulmonary microvascular injury following intestinal reperfusion.
59 Citations1994Richard H. Turnage, Karen S. Guice +1 more
The particular emphasis of this review is on events associated with intestinal ischemia-reperfusion, a common and important clinical event, and is designed to provide a basis for understanding this evolution.
Journal of Surgical ResearchIL-10 Is Not Protective in Intestinal Ischemia Reperfusion Injury
43 Citations2002Anthony Stallion, Tzuyung D. Kou +4 more
The results demonstrate that the anti-inflammatory cytokine IL-10 does not play a significant local or systemic protective role in this model of ischemia/reperfusion, and shows that the absolute serum concentration of IL-6 in the presence or the absence ofIL-10does not affect local or systems response to ischemic intestinal injury.
Seminars in Ultrasound CT and MRICT and MR diagnoses of intestinal ischemia
42 Citations2000Hyun Kwon Ha, Sung Eun Rha +2 more
Delayed diagnosis in equivocal cases can be avoided through an understanding of the patholophysiological aspects of mesenteric ischemia as they occur in a variety of other conditions, including: thromboembolism, bowel obstruction, neoplasm, vasculitis, inflammatory diseases, trauma, and drug or radiation therapy.
Current Opinion in NeurologyThe use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system
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This review describes the animal models used to study pathological processes leading to inflammation within the central nervous system that may be operating in multiple sclerosis and the use of these models in the design of more rational therapeutic strategies.
PerfusionSystemic inflammatory response and the splanchnic bed in cardiopulmonary bypass
38 Citations1996Sunil K. Ohri
The splanchnic bed undoubtedly undergoes sub-clinical injury in the majority of patients undergoing routine CPB, but this injury may be self-limiting or develop through a cascade of inflammatory mediators into multisystem organ failure.
Current Opinion in NeurologyThe use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system
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The results indicate that the response to stress is the combination of the type of injury and the genetic background of the subject, and illustrate the difficulty in predicting the inflammatory response and underlying mechanism based on cytokine plasma levels.
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