Elevated serum melatonin is associated with the nocturnal worsening of asthma
Journal of Allergy and Clinical ImmunologyPublished 1 September 2003
E Sutherland
Citations83
SJR quartileQ1
SJR score3.94
SNIP2.56
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TL;DR
Nocturnal asthma is associated with elevation and phase delay of peak serum melatonin levels, and Elevatedmelatonin levels might contribute to the pathogenesis of nocturnal Asthma.
Abstract
Nocturnal asthma is associated with elevation and phase delay of peak serum melatonin levels. Elevated melatonin levels might contribute to the pathogenesis of nocturnal asthma.
Keywords
MedicineNeuroscience
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The Cellular Aspects of Biorhythms
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De tels incidents et il en existe probablement d'autres influencent Ie rythme endogene, pouvant une fois accentuer, une autre fois, diminuer the signification des resultats statistiques.
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American Review of Respiratory DiseaseFactors Related to the Nocturnal Worsening of Asthma
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Journal of Pineal ResearchMelatonin modulates allergic lung inflammation
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American Review of Respiratory DiseaseCharacteristics of Peripheral Blood Eosinophils in Patients with Nocturnal Asthma
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Clinical Autonomic ResearchInfluence of melatonin on bovine pulmonary vascular and bronchial airway smooth muscle tone
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Life SciencesChanges in pulmonary mechanics induced by melatonin
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PubMedDiurnal rhythm of serum melatonin, ACTH and cortisol in asthma patients with long term glucocorticoid treatment.
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