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Pharmacodynamic Modeling for Change of Locomotor Activity by Methylphenidate in Rats

Pharmaceutical ResearchPublished 1 November 1997
Takao Aoyama, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada, Tatsuji Iga
Citations16
SJR quartileQ1
SJR score0.87
SNIP1.00

TL;DR

The developed model made it possible to explain the tolerance in DA increase and the complicated locomotive change induced by MPD, and may be useful for other DA reuptake inhibitors, such as amphetamine and methamphetamine.

Abstract

The developed model made it possible to explain the tolerance in DA increase and the complicated locomotive change induced by MPD, and may by useful for other DA reuptake inhibitors, such as amphetamine and methamphetamine.

Keywords

MedicineNeuroscience