Similarity Among the <b> <i>Drosophila</i> </b> (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family
SciencePublished 5 April 1996
Takeshi Todo, Haruko Ryo, Kazuo Yamamoto, Hiroyuki Toh, Taiichiro Inui, Hitoshi Ayaki
Citations244
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A gene encoding the Drosophila (6-4)photolyase was cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants.
Abstract
Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts[(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the Drosophila(6-4)photolyase ws cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the Drosophila (6-4)photolyase gene was also cloned from human cells.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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