Influence of fish-oil supplements on man
Proceedings of The Nutrition SocietyPublished 1 September 1985Open access
T. A. B. Sanders
Citations35
SJR quartileQ1
SJR score1.94
SNIP1.80
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TL;DR
Cod-liver oil played a central role in the isolation and discovery of vitamins A and D because it was known to cure night blindness, corneal xerosis and rickets and in fish-oil supplements since that dietary eicosapentaenoic acid may offer protection against acute myocardial infarction.
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Keywords
Biochemistry, Genetics and Molecular BiologyMedicineNursing
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PubMedEpidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.
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The effects of these supplements on plasma lipid concentrations, the fatty acid composition of platelet phosphoglycerides, template bleeding time and platelet aggregation induced by collagen and the prostaglandin analogue compound U46619 were studied.
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256 Citations1984D. Roger Illingworth, William S. Harris +1 more
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Thrombosis and HaemostasisThe Effect of N-6 and N-3 Polyunsaturated Fatty Acids on Hemostasis, Blood Lipids and Blood Pressure
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216 Citations1985T. A. B. Sanders, David Sullivan +2 more
Medical science symposia seriesDrugs Affecting Lipid Metabolism
216 Citations1993Alberico L. Catapano
The superfici al 1 ayers represented a new intima probably constituted in the process of repair when the previously present fatty streaks regressed, and showed the presence of deeply-seated cholesterol crystal s with no accompanyi ng ti ssue necrosi s.
ProstaglandinsThe effect of dietary supplementation of fish oil on experimental myocardial infarction
215 Citations1980Brenda R. Culp, William E.M. Lands +3 more
Dietary supplementation with fish oil may be beneficial in reducing myocardial damage associated with coronary artery thrombosis, according to the results of an investigation in dogs with experimentally induced my cardiac infarction.
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202 Citations1981Gerard Hornstra, E. Christ-Hazelhof +3 more
It is demonstrated that feeding cod-liver oil to rats leads to a considerable reduction in the formation of platelet TxA2 and of vascular PGI2, which contradict the suggested role of prostaglandins of the 3-series in thromboregulation.
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184 Citations1981Jan Brox, Jan-Eirik Angell Killie +2 more
Significant changes were observed in the plasma total fatty acid composition, particularly by CLO with an increase of the eicosapentaenoic acid (EPA): arachidonic acid (AA) ratio.
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There were changes in the fatty acid composition of plasma and platelet lipids which reflected dietary supplementation with n-3 fatty acids, notably an increase in the proportion of eicosapentaenoic and docosahexaenoic acids which occurred in a dose-dependent fashion.
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165 Citations1981T. A. B. Sanders, Katherine M. Younger
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Results suggest a close relationship of the observed fatty acid changes in individual platelet phospholipids to the altered hematological parameters and platelet-vessel wall interactions produced by cod-liver oil supplementation.
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114 Citations1980Mats Hámberg
5,8,11,14,17-[1-14C]Eicosapentaenoic acid was prepared biosynthetically from [1- 14C]arachidonic acid using the fungus, Saprolegnia parasitica, and three labeled compounds were identified.
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114 Citations1981J. Zahavi, John Betteridge +3 more
The results indicate that in vivo platelet "release reaction" and MDA formation are increased in hyperlipidemic patients, and suggest that the abnormal platelet function is related to the elevated levels of serum lipids and lipoproteins in the hyperlipidsemic patients and not only to the atherosclerotic changes associated withhyperlipidemia.
BMJEffect of treatment of hyperlipidaemia on haemostatic variables.
103 Citations1980R.S. Elkeles, Ranjan Chakrabarti +3 more
The haemostatic function of 11 men with hyperlipidaemia was measured before and after they were treated with a carbohydrate-reduced, fat-modified diet, which significantly reduced serum triglyceride and cholesterol concentrations.
Medical Clinics of North AmericaApproach to the Patient with Hyperlipidemia
95 Citations1982Richard J. Havel
The author classifies the major primary and secondary disorders, discusses the salient features of the primary disorders, summarizes screening and special diagnostic tests, and offers some general principles on the treatment of primary hyperlipidemia.
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The similarity of these product profiles to those reported for comparable microsomal incubations with other essential fatty acids suggest that microsome cytochrome P-450 monooxygenases were involved in docosahexaenoic acid.
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77 Citations1983T. A. B. Sanders, Michele C. Hochland
The MaxEPA but not the vegetable-oil supplement lowered the concentration of plasma triglycerides and increased that of high-density-lipoprotein-cholesterol and plasma total cholesterol concentrations were unaffected by the supplements.
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52 Citations1982Kerin O’Dea, AJ Sinclair
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Clinical ScienceEnzyme Induction and Serum and Lipoprotein Lipids: A Study of Glutethimide in Normal Subjects
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