THALAMOCORTICAL SYNAPSES
Progress in NeurobiologyPublished 1 April 1997
Manuel A. Castro‐Alamancos, Barry W. Connors
Citations114
SJR quartileQ1
SJR score2.55
SNIP1.61
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TL;DR
The properties of the afferents from thalamus to cortex are reviewed, some of the gaps in knowledge of thalamocortical pathways are identified, and the importance of these features for understanding how information is acquired, integrated, processed, stored and retrieved is identified.
Abstract
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored and retrieved by the thalamocortical system. This paper reviews the properties of the afferents from thalamus to cortex, and identifies some of the gaps in our knowledge of thalamocortical pathways.
Keywords
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Laminar field potentials in the cerebral cortex elicited by repetitive stimulation of thalamic nuclei were studied and used to define so-called augmenting and recruiting responses, indicating the existence of two different thalamocortical projection systems responsible for the deep and superficial thalamOCortical responses.
Cerebral CortexOrganization of Rodent Auditory Cortex: Anterograde Transport of PHA-L from MGv to Temporal Neocortex
136 Citations1993Lizabeth M. Romanski, J.E. LeDoux
It is suggested that TE1 (possibly excluding subarea TE1v) is the primary auditory cortex in the rat and appears to be the core target of MGv.
Journal of NeuroscienceGlutamate in thalamic fibers terminating in layer IV of primary sensory cortex
134 Citations1994Viktor Kharazia, Richard J. Weinberg
Glu is likely to be a neurotransmitter for thalamocortical relay neurons in primary somatic sensory, auditory, and visual cortex by injecting WGA-HRP in the corresponding thalamic sensory relay nuclei of rats.
NeuroscienceAnterograde tracer and field potential analysis of the neocortical layer I projection from nucleus ventralis medialis of the thalamus in cat
134 Citations1982L.L. Glenn, Junichi Hada +3 more
NeuroscienceDevelopmental expression ofα7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus
131 Citations1995Ron S. Broide, Lawrence T. O’Connor +3 more
The distribution of alpha 7 messenger RNA within the developing thalamocortical system parallels the distribution ofalpha-bungarotoxin binding sites and suggests that the receptor is localized on both thalamic cells and their cortical target neurons.
ScienceShort-Term Plasticity of a Thalamocortical Pathway Dynamically Modulated by Behavioral State
129 Citations1996Manuel A. Castro‐Alamancos, Barry W. Connors
Results from anesthetized rats showed that the augmenting response is initiated by pyramidal cells in layer V, and was found to be dynamically modulated by their behavioral state.
The Journal of Comparative NeurologyRadial organization of thalamic projections to the neocortex in the mouse
125 Citations1980Douglas O. Frost, Verne S. Caviness
The intracortical distributions of the thalamic projections to a large number of neocortical fields are studied by the anterograde degeneration method in the mouse, finding variations in the density and degree of divergence of projections and in the radial extent of individual tiers with respect to cytoarchitectonic layers.
Journal of NeurophysiologyInfluence of VPM afferents on putative inhibitory interneurons in S1 of the awake rabbit: evidence from cross-correlation, microstimulation, and latencies to peripheral sensory stimulation
123 Citations1995Harvey A. Swadlow
Test the hypothesis that responses of thalamocortical projection neurons and suspected cortical interneurons to very brief peripheral stimuli reflect a monosynaptic VPM input onto SINs and to examine the effects of such input.
The Journal of Comparative NeurologyAxonal trajectories between mouse somatosensory thalamus and cortex
120 Citations1987Kerry L. Bernardo, Thomas A. Woolsey
An in vitro brain slice preparation has been used to label fibers connecting the somatosensory thalamus and cortex of the mouse with horseradish peroxidase crystals, HRP, nonidet P‐40 detergent chips, or a solution of HRP/dimethylsulfoxide.
Progress in NeurobiologyThe role of the cerebello-thalamo-cortical pathway in skilled movement
120 Citations1995Malcolm Horne, Ernest Butler
Current data does not support a role for the CTC pathway in the initiation of movement or the control of trans-cortical reflexes, and the hypothesis that the cerebellum prevents terminal movement oscillations by predictively sending a message to the antagonist muscle to brake the movement is not supported.
Brain ResearchCorticothalamic neurons and thalamocortical terminal fields: An investigation in rat using horseradish peroxidase and autoradiography
119 Citations1975Stanley Jacobson, John Q. Trojanowski
The data derived from the rats which had received thalamic injections of HRP and [3H]leucine in combination indicated that the connections between cortex and thalamus are in general reciprocal.
Journal of NeuroscienceSpatiotemporal properties of short-term plasticity sensorimotor thalamocortical pathways of the rat
117 Citations1996Manuel A. Castro‐Alamancos, Barry W. Connors
Journal of NeurophysiologyEffects of 5-HT on thalamocortical synaptic transmission in the developing rat
117 Citations1994R. W. Rhoades, Carol A. Bennett‐Clarke +2 more
The results obtained in this study are consistent with the conclusion that 5-HT has a profound, but developmentally transient, presynaptic inhibitory effect upon thalamocortical transmission in the rat's somatosensory cortex.
Proceedings of the National Academy of SciencesSerotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons.
116 Citations1993Carol A. Bennett‐Clarke, M J Leslie +2 more
Results indicate that thalamocortical axons transiently express 5-HT1B receptors, and receptor binding autoradiography with neurochemical ablation of5-HT axons or electrolytic lesions of the dorsal thalamus are combined in an effort to determine the neural elements upon which the 5- HT1 B receptors were located.
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