Differential Contributions of<i>BRCA1</i>and<i>BRCA2</i>to Early-Onset Breast Cancer
New England Journal of MedicinePublished 15 May 1997Open access
Michael Krainer, Sandra Silva-Arrieta, Michael G. FitzGerald, Akira Shimada, Chikashi Ishioka, Ryunosuke Kanamaru
Citations210
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
Among young women with breast cancer, there are BRCA2 mutations that cause truncation of the extreme C terminus of the protein and that may be functionally silent, along with definite truncating mutations, which contribute to fewer cases of breast cancer among young women than do mutations in BRCa1.
Abstract
Germ-line mutations in BRCA2 contribute to fewer cases of breast cancer among young women than do mutations in BRCA1. Carriers of BRCA2 mutations may have a smaller increase in the risk of early-onset breast cancer.
Keywords
Biochemistry, Genetics and Molecular Biology
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