Transcriptional control: Versatile molecular glue
Current BiologyPublished 1 August 1996Open access
Ralf Janknecht, Tony Hunter
Citations233
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
CBP and p300 are versatile coactivators that physically connect many DNA-binding factors to the basal transcription machinery.
Abstract
CBP and p300 are versatile coactivators that physically connect many DNA-binding factors to the basal transcription machinery. Phosphorylation by cyclin-dependent or signal-induced protein kinases may regulate their function.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
CellA CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
2,177 Citations1996Yasutomi Kamei, Lan Xu +9 more
It is suggested that CBP/p300 serves as an integrator of multiple signal transduction pathways within the nucleus, in addition to distinct coactivators for function of nuclear receptors, CREB, and AP-1.
NatureNuclear protein CBP is a coactivator for the transcription factor CREB
1,453 Citations1994Roland P.S. Kwok, James R. Lundblad +7 more
Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
NatureRubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
1,220 Citations1995Fred Petrif, Rachel H. Giles +9 more
It is proposed that the loss of one functional copy of the CBP gene underlies the developmental abnormalities in RTS and possibly the propensity for malignancy.
NatureActivation of cAMP and mitogen responsive genes relies on a common nuclear factor
733 Citations1994Jonathan Arias, Arthur S. Alberts +6 more
It is reported here that micro-injection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter, and proposed that CBP is recruited to the promoter through interaction with certain phosphorylated factors, and may thus play a critical role in the transmission of inductive signals from cell surface receptor to the transcriptional apparatus.
NatureAdenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
590 Citations1995James R. Lundblad, Roland P.S. Kwok +3 more
The results indicate that the gene repression and cell immortalization functions associated with El A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression.
Molecular and Cellular BiologyPhosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism
415 Citations1996David Parker, Kevin Ferreri +6 more
The results demonstrate that, as in the case of tyrosine kinase pathways, signal transduction through serine/threonine Kinase pathways may also require protein interaction motifs which are capable of recognizing phosphorylated amino acids.
NatureControl of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
348 Citations1996Roland P.S. Kwok, Megan E. Laurance +6 more
It is shown that Tax can activate both the HTLV-1 and consensus cellular CREs, and it is proposed that this activation may occur through mechanisms that are differentially dependent on CREB phosphorylation.
Genes & DevelopmentCBP as a transcriptional coactivator of c-Myb.
348 Citations1996Pengcheng Dai, Hiroshi Akimaru +6 more
It is reported here that CBP is also a coactivator of the c-myb proto-oncogene product (c-Myb), which is a sequence-specific transcriptional activator.
The EMBO JournalCBP‐induced stimulation of c‐Fos activity is abrogated by E1A.
341 Citations1995Andrew J. Bannister, Tony Kouzarides
A model whereby E1A can modulate AP1 activity by directly competing for the CBP co‐activator protein is supported by a model whereby CBP binds c‐Fos in a phosphorylation‐independent manner in vitro, using a domain distinct from that required to bind CREB.
Proceedings of the National Academy of SciencesInvolvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.
335 Citations1995Caterina Missero, Enzo Calautti +5 more
Journal of Biological ChemistryHuman p300 Protein Is a Coactivator for the Transcription Factor MyoD
320 Citations1996Wuchao Yuan, Gianluigi Condorelli +3 more
It is shown that the repression of MyoD-mediated E box (MyoD consensus) reporter activity by E1A is correlated with its interaction with p300, indicating that p300 participates in Myo D-dependent transactivation.
PubMedStimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.
316 Citations1995Andrew J. Bannister, Thomas Oehler +3 more
It is shown that CBP also stimulates the activity of both c-Jun and v-Jun in vivo, consistent with a mechanism by which CBP acts as a co-activator protein for Jun dependent transcription by interacting with the Jun N-terminal activation domain.
Genes & DevelopmentRelief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.
311 Citations1995J S Lee, Katherine Galvin +5 more
Y1 is identified as a partner protein for p300 and a molecular mechanism for the relief of YY1-mediated repression by E1A is uncovered, revealing, for the first time, a YY 1/p300 complex that is targeted by E2F/RB.
PubMedp300 gene alterations in colorectal and gastric carcinomas.
285 Citations1996Masahiro Muraoka, M. Konishi +6 more
These are the first cases in which p300 gene has been found to be altered in both alleles, suggesting that inactivation of the p300 genes may be involved in the development of carcinomas, and that this gene may be the target of loss of 22q in carcinomas of the digestive tract.
The EMBO JournalInteraction of the co‐activator CBP with Myb proteins: effects on Myb‐specific transactivation and on the cooperativity with NF‐M.
213 Citations1996Michael Oelgeschläger, Ralf Janknecht +3 more
It is suggested that CBP can bridge between c‐Myb and NF‐M, thus providing an explanation for the strong synergism between these two proteins.
Proceedings of the National Academy of SciencesMultiple protein kinase A-regulated events are required for transcriptional induction by cAMP.
148 Citations1995Paul K. Brindle, Toshiaki Nakajima +1 more
Results demonstrate that, in addition to mediating Ser-133 phosphorylation of CREB, protein kinase A regulates additional proteins that are required for recruitment of the transcriptional apparatus to cAMP-responsive genes.
The EMBO JournalThe SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co‐activator, p300.
146 Citations1996Maria Laura Avantaggiati, Maria Luigia Carbone +4 more
The data indicate that the different specificities exhibited by Tag and E1a towards the various forms of p300 are reflected in vivo as a difference in the ability of these viral oncoproteins to modulate the expression of CRE‐containing genes.
PubMedRegulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.
120 Citations1996Ralf Janknecht, Alfred Nordheim
Combined phosphorylation of CBP by protein kinase A and mitogen-activated protein kinases appears to be non-cooperative, suggesting that CBP serves the function of a dampening integrator of two different signaling pathways.
Molecular and Cellular BiologyAnalysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.
108 Citations1991Peter Yaciuk, E Morán
PubMedFunctional interactions within adenovirus E1A protein complexes.
103 Citations1994Dominique J. Barbeau, R. Charbonneau +3 more
One role of E1A proteins in signal transduction and regulation of the cell cycle may be to control the biological activity of p107, p130 and p300 by enhancing their phosphorylation through complex formation.
The EMBO JournalPhosphorylation of the adenovirus E1A‐associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.
97 Citations1995Issay Kitabayashi, Richard Eckner +5 more
The results suggest that p300 is part of the DRF complexes, that it is differentially phosphorylated in undifferentiated versus differentiated cells and thatIt is likely involved in regulating transcription of the c‐jun gene during F9 cell differentiation.
Journal of VirologyE1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity
63 Citations1995Hongjie Wang, E Morán +1 more
Conservation of a spacer region between the two binding sites that is required for simultaneous binding and efficient induction of proliferation supports the concept that the E1A protein structure has evolved to facilitate simultaneous binding.
Journal of Biological ChemistryAn Inactivating Point Mutation Demonstrates That Interaction of cAMP Response Element Binding Protein (CREB) with the CREB Binding Protein Is Not Sufficient for Transcriptional Activation
61 Citations1995Peiqing Sun, Richard A. Maurer
It is determined that replacement of Ser of CREB with Asp greatly decreases the ability of the cAMP-dependent protein kinase to activate CREB, suggesting that although the binding ofCREB to CBP is necessary, it is not sufficient for transcriptional responses to cAMP.
PubMedThe adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation.
44 Citations1996Paul H.M. Smits, L. De Wit +2 more
It is shown here that overexpressed p300 can counteract the repressive effect of E1A on the collagenase promoter, and it is indicated that one of the mechanisms by which E 1A modulates transcription and transforms cells is via transcriptional adaptors like p300 and CBP.
PubMedThe adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.
41 Citations1994Ambika C. Banerjee, Anthony J. Recupero +4 more
In vitro analysis of p300 shows that p300 can be used as a substrate for the cyclin-dependent p33cdk2 and p34cdc2 kinases, and proposes that E1A might be antagonistic to these enzymes in phosphorylating p300, indicating a possible novel function by which E1B can interfere with cellular pathways.