Norepinephrine in Chronic Paranoid Schizophrenia: Above-Normal Levels in Limbic Forebrain
SciencePublished 28 April 1978
Irene J. Farley, Kathleen Price, Edward J. McCullough, John H. N. Deck, Walter Hordynski, Oleh Hornykiewicz
Citations271
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
In postmortem examination of brains of patients with chronic paranoid schizophrenia, above-normal norepinephrine levels were measured in the ventral septum, the bed nucleus of the stria terminalis, the nucleus accumbens, and the mammillary bodies, suggesting the possibility of a malfunction of limbic noradrenergic mechanisms in schizophrenia, especially the paranoid variety.
Abstract
In postmortem examination of brains of four patients with chronic paranoid schizophrenia, above-normal norepinephrine levels were measured in the ventral septum, the bed nucleus of the stria terminalis, the nucleus accumbens, and the mammillary bodies. No changes were detected in other limbic forebrain regions, including the hypothalamus and the medial olfactory (preoptic) area. The results point to the possibility of a malfunction of limbic noradrenergic mechanisms in schizophrenia, especially the paranoid variety.
Keywords
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