Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
SciencePublished 16 June 1995
Neil Risch, Heping Zhang
Citations533
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans.
Abstract
Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extreme trait value. The majority of such pairs provide little power to detect linkage; only pairs that are concordant for high values, low values, or extremely discordant pairs (for example, one in the top 10 percent and the other in the bottom 10 percent of the distribution) provide substantial power. Focus on discordant pairs can reduce the amount of genotyping necessary over conventional designs by 10- to 40-fold.
Keywords
Biochemistry, Genetics and Molecular Biology
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