Elicitation of intraspecific defence reactions in the rat from midbrain periaqueductal grey by microinjection of kainic acid, without neurotoxic effects
Neuroscience LettersPublished 1 June 1988
Richard Bandler, Antoine Depaulis
Citations94
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Microinjection of 40 pmol of the neuroexcitotoxin, kainic acid in the midbrain periaqueductal grey region (PAG) evoked a significant increase in both defensive and immobile behaviours in rats tested in a social situation, identical to the rat's natural defensive reaction to attack by a conspecific.
Abstract
Microinjection of 40 pmol of the neuroexcitotoxin, kainic acid (KA) in the midbrain periaqueductal grey region (PAG) evoked a significant increase in both defensive and immobile behaviours in rats tested in a social situation. The evoked reactions appeared identical to the rat's natural defensive reaction to attack by a conspecific, although they were evoked by the presence, rather than the attack, of another rat. The long duration and natural appearance of the KA-evoked reactions stand in contrast to the short, 'explosive' reactions evoked by injection in the PAG of other excitant amino acids. There was no behavioural evidence of a diminution in the effect of repeated injections of KA in the PAG, nor was there any histological evidence of neurotoxicity.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
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