MacroH2A, a Core Histone Containing a Large Nonhistone Region
SciencePublished 4 September 1992
John R. Pehrson, Victor A. Fried
Citations334
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A Histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes and has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors.
Abstract
A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.
Keywords
Biochemistry, Genetics and Molecular Biology
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